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Novel coupled nanopore platform offers greater precision for detecting molecules
Artist depiction of DNA moving through a nanopore system.

Marija Drndić of the School of Arts & Sciences and Dimitri Monos of the Perelman School of Medicine and Children’s Hospital of Philadelphia led a team of researchers who developed a new nanostructure platform that allows for more precise detection and control of biomolecules, such as DNA and proteins. This exciting new platform signals a new era of synthetic biology, paving the way for enhanced DNA sequencing and protein conformation detection.

(Image: Courtesy of artist) 

Novel coupled nanopore platform offers greater precision for detecting molecules

An interdisciplinary team of researchers from Penn have created the first ever reusable coupled nanopore platform for detecting and guiding molecules, findings could pave the way for much improved DNA sequencing and molecule identification.
Understanding diabetes and oral health
Two students in lab coats surround a professor in a suit.

From left: Su Ah Kim, professor of periodontics Dana Graves, and Sanan Gueyikian.

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Understanding diabetes and oral health

Two undergraduates, supported by PURM, worked on research projects this summer with the Graves Lab to contribute to the knowledge of diabetes’ impact on oral wound healing and periodontal disease.
New biomarkers can help target treatment for chronic skin disease
Microscopic view of granulomatous tissue.

Cellular view of granulomatous tissue.

(Image: iStock/Md Saiful Islam Khan)

New biomarkers can help target treatment for chronic skin disease

Researchers at Penn Medicine have found a pathway in certain lymphoid cells that, once targeted, inhibit granulomas from forming in patients with sarcoidosis.

Alex Gardner

Gene therapy trial sees massive improvement in vision
Closeup view of an eyeball with a vision test graphic.

Image: iStock/murat4art

Gene therapy trial sees massive improvement in vision

Patients with a rare disease affecting their sight have experienced quick vision improvements that sustained for the full yearlong Penn Medicine study, with some experiencing a 10,000-fold improvement in their vision.
Weight management drug does not increase risk of depression or suicidal behavior
A person opening the top of a semaglutide prescription pen.

Image: iStock/imyskin

Weight management drug does not increase risk of depression or suicidal behavior

In new clinical trials, researchers from Penn Medicine find that for people without known major psychopathology, taking semaglutide for weight loss are at no increased risk of mental health issues.

From Penn Medicine News

Boosting the frequency of sound waves to make the next generation of wireless devices
Researchers in a clean room pointing at a microscope.

Under the guidance of Yue Jiang(left), a Ph.D. candidate in the Charlie Johnson research group in the School of Arts & Sciences, Vincent Kerler (right) conducted this work through the Penn Undergraduate Researching Mentoring Program, a 10-week opportunity from the Center for Undergraduate Research and Fellowships. The program provides rising second- and third-year students with $5,000 awards to work alongside Penn faculty.

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Boosting the frequency of sound waves to make the next generation of wireless devices

Vincent Kerler, a second-year student in the College of Arts and Sciences, spent the summer running simulations as part of Charlie Johnson’s research on topological insulators.
The mechanics of collaboration
Portrait of Xinlan Emily Hu

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The mechanics of collaboration

Penn Ph.D. student Xinlan Emily Hu leads a group of budding engineers and social scientists who study communication across teams. The group has developed a new toolkit aimed at helping researchers analyze and measure teamwork.
NASA’s Roman Space Telescope will investigate the history of galaxies
artist's concept of the Andromeda galaxy's stellar halo, depicted with exaggerated brightness and density, highlighting the extent of this faint and loosely connected collection of stars that surrounds the galaxy.

Robyn Sanderson and Adrien Thob of the School of Arts & Sciences are part of a team of astronomers using NASA’s upcoming Nancy Grace Roman Space Telescope to uncover the “fossil record” of the universe as they look to clues to unearth key insights into its formation.

(Image: Courtesy of NASA, Ralf Crawford (STScI))

NASA’s Roman Space Telescope will investigate the history of galaxies

Robyn Sanderson and collaborators are unearthing the history of the universe’s formation by looking for clues that reveal its “galactic fossil record.”
Court no-shows: A systemic issue
The courtyard at City Hall in Philadelphia.

Image: iStock/Alexandre Tziripouloff

Court no-shows: A systemic issue

Penn Carey Law professor Sandy Mayson has found that failure-to-appear plays a central role in criminal case processing in Philadelphia.

From Penn Carey Law

1 min. read

Uncovering new antibiotics inside the human gut
Microscopic rendering of bacterial in the small intestines.

Image: iStock/ChrisChrisW

Uncovering new antibiotics inside the human gut

Researchers from Penn Engineering, led by César de la Fuente, have leveraged AI to discover dozens of potential new antibiotics in the human gut microbiome.

Ian Scheffler