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No evidence that CAR T cell therapy causes secondary cancers
Person in gloves holding a medical bag of liquids.

Image: Courtesy of Penn Medicine

No evidence that CAR T cell therapy causes secondary cancers

In a new study, researchers at Penn Medicine looked for—and did not find—examples where the process of generating CAR T cells caused malignancy.

Kelsey Geesler

Borrowing nature’s blueprint: How scientists replicated bone marrow
A chip with bioengineered bone marrow.

The new chip will allow for automated experiments, and can be connected to chip-based models of other organ systems, like the lungs.

(Image: Dan Huh)

Borrowing nature’s blueprint: How scientists replicated bone marrow

A collaborative research team from Penn Engineering, Penn Medicine, and the Children’s Hospital of Philadelphia have developed a chip that mimics human bone marrow.

Ian Scheffler

Standardizing provider assessments to aid veterans at risk of suicide
An Army veteran speaking with a medical professional.

Image: iStock/Drazen Zigic

Standardizing provider assessments to aid veterans at risk of suicide

A Penn Medicine study of nearly 39,000 health records is the first to examine access to firearms and opioids, and completion of related interventions, among veterans at risk for suicide receiving care at the VA.

Eric Horvath

The compassionate team behind CAR T cancer breakthroughs
From left, research coordinator Nicolas Sarmiento, project manager Reenie Martins, research coordinator Lee Dengel, and trial sample coordinator Rutendo Manyeka in a hospital.

(From left) Research coordinator Nicolas Sarmiento, project manager Reenie Martins, research coordinator Lee Dengel, and trial sample coordinator Rutendo Manyeka document and prepare paperwork required for T-cell infusion.

(Image: Courtesy of Penn Medicine News)

The compassionate team behind CAR T cancer breakthroughs

The clinical trial support staff at Penn Medicine and the Abramson Cancer Center have helped execute the team science that brings research discoveries from the lab bench to the bedside.

From Penn Medicine News

Avian flu: An explainer
Scott Hensley.

Denise Henhoeffer

Avian flu: An explainer

In a video, Penn Medicine’s Scott Hensley gives an overview on what people should know about the avian flu virus and vaccine developments.

New ways to modulate cell activity remotely
3D rendering of cells on a blue backdrop

Cells are dynamic, fast-changing, complex, tiny, and often hard-to-see in environments that don’t always behave in predictable ways when exposed to external stimuli. Now, researchers led by Lukasz Bugaj of the School of Engineering and Applied Science have found new ways to modulate cell activity remotely.

(Image: iStock/Maksim Tkachenko)

New ways to modulate cell activity remotely

Penn researchers use temperature to guide cellular behavior, promising better diagnostics and targeted therapies.
The motor driving Penn’s biomedical research
Michael Ostap

Michael Ostap is the interim senior vice dean and chief scientific officer of the Perelman School of Medicine.

(Image: Courtesy of Penn Medicine Magazine)

The motor driving Penn’s biomedical research

For nearly three decades, interim senior vice dean and chief scientific officer of the Perelman School of Medicine Michael Ostap has investigated how molecules such as myosin feel force, in an effort to understand how cellular mutations cause disease.

Meredith Lidard Kleeman for Penn Medicine Magazine

Science behind genetic testing for identifying risk of opioid misuse remains unproven
A scientist with a pipette and a test tube with a computer screen in the background.

Image: iStock/Cavan Images

Science behind genetic testing for identifying risk of opioid misuse remains unproven

A new report from researchers at the Perelman School of Medicine and Crescenz VA Medical Center has evaluated a genetic test for opioid use disorder that recently received pre-marketing approval by the FDA, finding that the genes comprising it do not accurately identify individuals likely to develop the disorder.

Eric Horvath