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Penn Medicine: Paths Not Taken: Notch Signaling Pathway Keeps Immature T Cells on the Right Track

Penn Medicine: Paths Not Taken: Notch Signaling Pathway Keeps Immature T Cells on the Right Track

The lab of Avinash Bhandoola, PhD, professor of Pathology and Laboratory Medicine, has studied the origins of T cells for many years. One protein called Notch, which has well-known roles in the development of multiple tissues, plays an essential role in triggering T-cell development.

Karen Kreeger

Epigenetic Changes May Explain Chronic Kidney Disease, Penn Study Shows

Epigenetic Changes May Explain Chronic Kidney Disease, Penn Study Shows

The research of physician-scientist Katalin Susztak, MD, PhD, associate professor of Medicine in the Renal Electrolyte and Hypertension Division, at the Perelman School of Medicine, University of Pennsylvania, strives to understand the molecular roots an

Karen Kreeger

Penn Medicine: Targets of Anticancer Drugs Have Broader Functions than What Their Name Suggests

Penn Medicine: Targets of Anticancer Drugs Have Broader Functions than What Their Name Suggests

Drugs that inhibit the activity of enzymes called histone deacetylases (HDACs) are being widely developed for treating cancer and other diseases, with two already on the market. Researchers at the Perelman School of Medicine, University of Pennsylvania, show that a major HDAC still functions in mice even when its enzyme activity is abolished, suggesting that the beneficial effects of HDAC inhibitors may not actually be through inhibiting HDAC activity, and thus warranting the reassessment of the molecular targets of this class of drugs.

Karen Kreeger

Penn Medicine: New Study Finds Similar Outcomes for Repair or Replacement of Damaged Heart Valves

Penn Medicine: New Study Finds Similar Outcomes for Repair or Replacement of Damaged Heart Valves

New research presented today at the 2013 Scientific Sessions of the American Heart Association by researchers at the Perelman School of Medicine at the University of Pennsylvania found no difference in outcomes at one-year between two recommended surgical options for treating ischemic mitral regurgitation (IMR) – repair of the leaky valve or its replacem

Jessica Mikulski

Penn Produces Graphene Nanoribbons With Nanopores for Fast DNA Sequencing

Penn Produces Graphene Nanoribbons With Nanopores for Fast DNA Sequencing

The instructions for building all of the body’s proteins are contained in a person’s DNA, a string of chemicals that, if unwound and strung end to end, would form a sentence 3 billion letters long.

Evan Lerner

Penn Medicine Study Shows Women's Risk of Depression Lowers After Final Menstrual Period

Penn Medicine Study Shows Women's Risk of Depression Lowers After Final Menstrual Period

Risk of depression is lower in menopausal women after their final menstrual period (FMP) but a history of depression increases the risk of depressive symptoms both before and after menopause, according to a new study from researchers at the Perelman School of Medicine at the University of Pennsylvania.

Katie Delach

Penn Dental Medicine Team Identifies Molecule Critical to Healing Wounds

Penn Dental Medicine Team Identifies Molecule Critical to Healing Wounds

Skin provides a first line of defense against viruses, bacteria and parasites that might otherwise make people ill. When an injury breaks that barrier, a systematic chain of molecular signaling launches to close the wound and re-establish the skin’s layer of protection.

Katherine Unger Baillie

Evolution Can Select for Evolvability, Penn Biologists Find

Evolution Can Select for Evolvability, Penn Biologists Find

Evolution does not operate with a goal in mind; it does not have foresight. But organisms that have a greater capacity to evolve may fare better in rapidly changing environments. This raises the question: does evolution favor characteristics that increase a species’ ability to evolve?

Katherine Unger Baillie

Sons of Cocaine-Using Fathers May Resist Addiction to Drug, Penn Medicine Study Suggests

Sons of Cocaine-Using Fathers May Resist Addiction to Drug, Penn Medicine Study Suggests

A father’s cocaine use may make his sons less sensitive to the drug and thereby more likely to resist addictive behaviors, suggests new findings from an animal study presented by Penn Medicine researchers at Neuroscience 2013, the annual meeting of the Society for Neuroscience.

Steve Graff

Penn Medicine: Study Shows Moms May Pass Effects of Stress to Offspring Via Vaginal Bacteria and Placenta

Penn Medicine: Study Shows Moms May Pass Effects of Stress to Offspring Via Vaginal Bacteria and Placenta

Pregnant women may transmit the damaging effects of stress to their unborn child by way of the bacteria in their vagina and through the placenta, suggest new findings from two animal studies presented by researchers at the University of Pennsylvania at Neuroscience 2013, the annual meeting of the Society for Neuroscience.

Steve Graff