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Penn Medicine: APOL1 Gene Speeds Kidney Disease Progression and Failure in Blacks, Regardless of Diabetes Status

Penn Medicine: APOL1 Gene Speeds Kidney Disease Progression and Failure in Blacks, Regardless of Diabetes Status

A large study co-led by Penn Medicine published this week in the New England Journal of Medicine found that African Americans with the APOL1 gene variant experience faster progression of chronic kidney disease (CKD) and have a significantly increased risk of kidney failure, regardless of their diabetes status.

Steve Graff

A Tale of Two Genes: Penn Team Elucidates Evolution of Bitter Taste Sensitivity

A Tale of Two Genes: Penn Team Elucidates Evolution of Bitter Taste Sensitivity

It’s no coincidence that the expression “to leave a bitter taste in one’s mouth” has a double meaning; people often have strong negative reactions to bitter substances, which, though found in healthful foods like vegetables, can also signify toxicity. For this reason, the ability to sense bitterness likely played an important role in human evolution.

Katherine Unger Baillie

Penn Study Identifies New Trigger for Breast Cancer Metastasis

Penn Study Identifies New Trigger for Breast Cancer Metastasis

For years, scientists have observed that tumor cells from certain breast cancer patients with aggressive forms of the disease contained low levels of mitochondrial DNA. But, until recently, no one was able to explain how this characteristic influenced disease progression. 

Katherine Unger Baillie

Penn Researchers Identify Molecular Link Between Gut Microbes and Intestinal Health

Penn Researchers Identify Molecular Link Between Gut Microbes and Intestinal Health

It’s well established that humans maintain a symbiotic relationship with the trillions of beneficial microbes that colonize their bodies. These organisms, collectively called the microbiota, help digest food, maintain the immune system, fend off pathogens, and more.

Karen Kreeger

Sexual Function Dramatically Improves in Women Following Bariatric Surgery, Penn Study Finds

Sexual Function Dramatically Improves in Women Following Bariatric Surgery, Penn Study Finds

The first study to look extensively at sexual function in women who underwent bariatric surgery found that significant improvements in overall sexual function, most reproductive hormones and in psychological status were maintained over two years following surgery.

Kim Menard

Penn Student Moves from Military Service to Family Medicine

Penn Student Moves from Military Service to Family Medicine

Many people decide to go back to school later in life to pursue an entirely different career. At the University of Pennsylvania, one non-traditional student’s experiences revolutionized his way of thinking about humanity, and he says the switch from chasing bad guys in Afghanistan to healing sick patients isn’t really so different, after all.