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Penn Researchers Find Molecular Key to Exhaustion Following Sleep Deprivation

Penn Researchers Find Molecular Key to Exhaustion Following Sleep Deprivation

It happens to everyone: You stay up late one night to finish an assignment, and the next day, you’re exhausted. Humans aren’t unique in that; all animals need sleep, and if they don’t get it, they must make it up.

Kim Menard

Penn Medicine Team Draws Map to Avoid Detours on Road to HIV Treatment Success

Penn Medicine Team Draws Map to Avoid Detours on Road to HIV Treatment Success

Addressing on the challenges that accompany transitions between health care settings could be a key strategy for improving clinical outcomes for people living with HIV, according to researchers from the Perelman School of Medicine at the University of Pennsylvania.

Holly Auer

Penn Medicine: Donor Smoking and Recipient Obesity Tied to Higher Rates of Death and Lung Injury After Lung Transplantation

Penn Medicine: Donor Smoking and Recipient Obesity Tied to Higher Rates of Death and Lung Injury After Lung Transplantation

PHILADELPHIA — A multi-institution study led by researchers at the Perelman School of Medicine at the University of Pennsylvania has identified several important risk factors, including a donor’s smoking history and recipient obesity, linked to severe primary graft dysfunction (PGD), the major cause of serious illness and death after lung transplantation. PGD is a common complication that affects up to 25 percent of lung transplant patients shortly after surgery.  The study also found that some previously identified risk factors, including donor sex, race, age, and means of death, were not associated with PGD.

Jessica Mikulski

Penn Study: How the Body's Energy Molecule Transmits Three Types of Taste

Penn Study: How the Body's Energy Molecule Transmits Three Types of Taste

Saying that the sense of taste is complicated is an understatement, that it is little understood, even more so. Exactly how cells transmit taste information to the brain for three out of the five primary taste types was pretty much a mystery, until now.

Karen Kreeger

Penn Medicine: Colonoscopy Screening Reduces Risk of Advanced Colorectal Cancer

Penn Medicine: Colonoscopy Screening Reduces Risk of Advanced Colorectal Cancer

PHILADELPHIA — A new study led by a researcher at the Perelman School of Medicine at the University of Pennsylvania adds support to current medical recommendations stating that screening colonoscopy substantially reduces an average-risk adult’s likelihood of being diagnosed with advanced colorectal cancer (CRC) in either

Katie Delach

Penn Medicine: Adding to the List of Disease-Causing Proteins in Brain Disorders

Penn Medicine: Adding to the List of Disease-Causing Proteins in Brain Disorders

PHILADELPHIA — A multi-institution group of researchers has found new candidate disease proteins for neurodegenerative disorders. James Shorter, Ph.D., assistant professor of Biochemistry and Biophysics at the Perelman School of Medicine, University of Pennsylvania, Paul Taylor, M.D., PhD, St. Jude Children’s Hospital, and colleagues describe in an advanced online publication of Nature that mutations in prion-like segments of two RNA-binding proteins are associated with a rare inherited degeneration disorder affecting muscle, brain, motor neurons and bone (called multisystem proteinopathy) and one case of the familial form of amyotrophic lateral sclerosis (ALS).

Karen Kreeger