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Penn Medicine Team Draws Map to Avoid Detours on Road to HIV Treatment Success

Penn Medicine Team Draws Map to Avoid Detours on Road to HIV Treatment Success

Addressing on the challenges that accompany transitions between health care settings could be a key strategy for improving clinical outcomes for people living with HIV, according to researchers from the Perelman School of Medicine at the University of Pennsylvania.

Holly Auer

Penn Medicine: Donor Smoking and Recipient Obesity Tied to Higher Rates of Death and Lung Injury After Lung Transplantation

Penn Medicine: Donor Smoking and Recipient Obesity Tied to Higher Rates of Death and Lung Injury After Lung Transplantation

PHILADELPHIA — A multi-institution study led by researchers at the Perelman School of Medicine at the University of Pennsylvania has identified several important risk factors, including a donor’s smoking history and recipient obesity, linked to severe primary graft dysfunction (PGD), the major cause of serious illness and death after lung transplantation. PGD is a common complication that affects up to 25 percent of lung transplant patients shortly after surgery.  The study also found that some previously identified risk factors, including donor sex, race, age, and means of death, were not associated with PGD.

Jessica Mikulski

Penn Medicine: Colonoscopy Screening Reduces Risk of Advanced Colorectal Cancer

Penn Medicine: Colonoscopy Screening Reduces Risk of Advanced Colorectal Cancer

PHILADELPHIA — A new study led by a researcher at the Perelman School of Medicine at the University of Pennsylvania adds support to current medical recommendations stating that screening colonoscopy substantially reduces an average-risk adult’s likelihood of being diagnosed with advanced colorectal cancer (CRC) in either

Katie Delach

Penn Medicine: Adding to the List of Disease-Causing Proteins in Brain Disorders

Penn Medicine: Adding to the List of Disease-Causing Proteins in Brain Disorders

PHILADELPHIA — A multi-institution group of researchers has found new candidate disease proteins for neurodegenerative disorders. James Shorter, Ph.D., assistant professor of Biochemistry and Biophysics at the Perelman School of Medicine, University of Pennsylvania, Paul Taylor, M.D., PhD, St. Jude Children’s Hospital, and colleagues describe in an advanced online publication of Nature that mutations in prion-like segments of two RNA-binding proteins are associated with a rare inherited degeneration disorder affecting muscle, brain, motor neurons and bone (called multisystem proteinopathy) and one case of the familial form of amyotrophic lateral sclerosis (ALS).

Karen Kreeger

Penn Campaign Raises $4.3 Billion, Transforming the University

Penn Campaign Raises $4.3 Billion, Transforming the University

After seven years of widespread support and alumni participation, the University of Pennsylvania culminated its Making History Campaign, raising $4.3 billion, strengthening Penn’s position among the world’s foremost universities and making major breakthroughs in addressing society’s most complex challenges, Penn President Amy Gutmann announced today.

Stephen MacCarthy

Penn Medicine: Tweaking Gene Expression to Repair Lungs

Penn Medicine: Tweaking Gene Expression to Repair Lungs

PHILADELPHIA — Lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) are on the rise, according to the American Lung Association and the National Institutes of Health.

Karen Kreeger

Penn Researchers Develop Protein ‘Passport’ That Helps Nanoparticles Get Past Immune System

Penn Researchers Develop Protein ‘Passport’ That Helps Nanoparticles Get Past Immune System

The body’s immune system exists to identify and destroy foreign objects, whether they are bacteria, viruses, flecks of dirt or splinters. Unfortunately, nanoparticles designed to deliver drugs, and implanted devices like pacemakers or artificial joints, are just as foreign and subject to the same response.

Evan Lerner