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Penn Medicine: Adding to the List of Disease-Causing Proteins in Brain Disorders

Penn Medicine: Adding to the List of Disease-Causing Proteins in Brain Disorders

PHILADELPHIA — A multi-institution group of researchers has found new candidate disease proteins for neurodegenerative disorders. James Shorter, Ph.D., assistant professor of Biochemistry and Biophysics at the Perelman School of Medicine, University of Pennsylvania, Paul Taylor, M.D., PhD, St. Jude Children’s Hospital, and colleagues describe in an advanced online publication of Nature that mutations in prion-like segments of two RNA-binding proteins are associated with a rare inherited degeneration disorder affecting muscle, brain, motor neurons and bone (called multisystem proteinopathy) and one case of the familial form of amyotrophic lateral sclerosis (ALS).

Karen Kreeger

Penn Campaign Raises $4.3 Billion, Transforming the University

Penn Campaign Raises $4.3 Billion, Transforming the University

After seven years of widespread support and alumni participation, the University of Pennsylvania culminated its Making History Campaign, raising $4.3 billion, strengthening Penn’s position among the world’s foremost universities and making major breakthroughs in addressing society’s most complex challenges, Penn President Amy Gutmann announced today.

Stephen MacCarthy

Penn Medicine: Tweaking Gene Expression to Repair Lungs

Penn Medicine: Tweaking Gene Expression to Repair Lungs

PHILADELPHIA — Lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) are on the rise, according to the American Lung Association and the National Institutes of Health.

Karen Kreeger

Sleep-wake cycles on a 520-day trip to Mars

Sleep-wake cycles on a 520-day trip to Mars

On June 3, 2010, a crew of six male astronauts from Russia, Italy, and China waved goodbye to their families, entered the spaceship that would be their home for the next 17 months, and prepared for liftoff. Next stop: Mars.

Brian M. Schleter

Simulating real-world health care

Simulating real-world health care

When US Airways captain Chesley “Sully” Sullenberger III made a successful emergency landing of his plane on the Hudson River in 2009, it wasn’t because he got lucky. In fact, Sullenberger, like other pilots before and after him, relied on a kind of finely honed muscle memory, having been prepared in flight simulators for emergencies, freak occurrences, and the unthinkable.
Penn Researchers Develop Protein ‘Passport’ That Helps Nanoparticles Get Past Immune System

Penn Researchers Develop Protein ‘Passport’ That Helps Nanoparticles Get Past Immune System

The body’s immune system exists to identify and destroy foreign objects, whether they are bacteria, viruses, flecks of dirt or splinters. Unfortunately, nanoparticles designed to deliver drugs, and implanted devices like pacemakers or artificial joints, are just as foreign and subject to the same response.

Evan Lerner

Penn Study Shows Long-Term Efficacy of Minimally Invasive Therapy for Patients with Barrett's Esophagus

Penn Study Shows Long-Term Efficacy of Minimally Invasive Therapy for Patients with Barrett's Esophagus

PHILADELPHIA — According to a new study by researchers at the Perelman School of Medicine at the University of Pennsylvania, patients with Barrett's esophagus and early or pre-cancerous cells have been shown to significantly benefit from minimally invasive therapy deliver

Katie Delach

Penn Researchers Help Show That Blood Plasma Is Thicker Than Water

Penn Researchers Help Show That Blood Plasma Is Thicker Than Water

PHILADELPHIA — For decades, researchers thought that blood plasma behaved like water. But, according to new research from the University of Pennsylvania and Saarland University in Germany, plasma is more elastic and viscous than water, and, like ketchup, its flow properties depend on the pressure it is under.

Evan Lerner