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By altering bone marrow, ‘training’ can prepare innate immune system for future challenges
Hajishengallis, an expert in the immune mechanisms behind the gum disease periodontitis

Hajishengallis, an expert in the immune mechanisms behind the gum disease periodontitis, worked with an international team to show that the innate immune system--typically thought to lack immune memory--can in fact be trained to "remember" past threats.

By altering bone marrow, ‘training’ can prepare innate immune system for future challenges

George Hajishengallis of the School of Dental Medicine and an international team of colleagues have found that “training” the immune system causes changes in the precursors of immune cells in the bone marrow. These changes could facilitate a more robust response to future infections or even enable the immune system to regenerate faster after chemotherapy.

Katherine Unger Baillie

Penn Engineers: Bone Marrow Transplant Stem Cells Can 'Swim' Upstream

Penn Engineers: Bone Marrow Transplant Stem Cells Can 'Swim' Upstream

When a cancer patient receives a bone marrow transplant, time is of the essence. Healthy stem cells, which can restart the production of blood cells and immune system components after a patient’s own are compromised, need to make their way from the circulatory system into the bones as quickly as possible.

Evan Lerner , Ali Sundermier

Weekly Fish Consumption Linked to Better Sleep, Higher IQ

Weekly Fish Consumption Linked to Better Sleep, Higher IQ

Children who eat fish at least once a week sleep better and have IQ scores that are 4 points higher, on average, according to new findings from the University of Pennsylvania published in Scientific Reports.

Michele W. Berger

Commonalities in Late Stages of Different Inherited Blinding Diseases Suggest Targets for Therapy

Commonalities in Late Stages of Different Inherited Blinding Diseases Suggest Targets for Therapy

Gene therapy holds promise for treating a variety of diseases, including some inherited blinding conditions. But for a gene therapy to be effective, one must know the precise gene responsible for a given individual’s disorder and develop a tailored treatment.

Katherine Unger Baillie

LGBQ adolescents at much greater risk of suicide than heterosexual counterparts

LGBQ adolescents at much greater risk of suicide than heterosexual counterparts

Specifically, 40 percent of sexual-minority adolescents seriously considered suicide compared to 15 percent of their heterosexual counterparts, and nearly a quarter attempted suicide compared to approximately 6 percent of those in the sexual majority.

Michele W. Berger

FDA Approves Gene Therapy for Inherited Blindness Developed by Penn and CHOP

FDA Approves Gene Therapy for Inherited Blindness Developed by Penn and CHOP

In a historic move, the U.S. Food and Drug Administration (FDA) today approved a gene therapy initially developed by researchers at the University of Pennsylvania and Children’s Hospital of Philadelphia (CHOP) for the treatment of a rare, inherited form of retinal blindness.

Katie Delach

Coalition Seeks to Increase Transparency on Life Sciences Career Prospects

Coalition Seeks to Increase Transparency on Life Sciences Career Prospects

Nine American research universities and a major cancer institute today announced plans to give would-be life scientists clear, standardized data on graduate school admissions, education and training opportunities and career prospects.

Katherine Unger Baillie , Dennis O'Shea

New Penn Method of Stabilizing Peptides Opens the Door to Better Therapeutic and Imaging Techniques

New Penn Method of Stabilizing Peptides Opens the Door to Better Therapeutic and Imaging Techniques

For many people with advanced Type 2 diabetes, taking insulin is a regular part of their routine, helping them control their blood sugar by signaling the metabolism of glucose. But recently, researchers have been investigating GLP-1, a peptide that gets activated when people eat, triggering insulin through a more natural pathway.

Ali Sundermier