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Penn Medicine: Cell Aging Slowed by Putting Brakes on Noisy Transcription

Penn Medicine: Cell Aging Slowed by Putting Brakes on Noisy Transcription

Working with yeast and worms, researchers found that incorrect gene expression is a hallmark of aged cells and that reducing such “noise” extends lifespan in these organisms. The team published their findings this month in Genes & Development.

Karen Kreeger

Sleepy Fruitflies Get Mellow: Sleep Deprivation Reduces Aggression, Mating Behavior in Flies, Penn Study Finds

Sleepy Fruitflies Get Mellow: Sleep Deprivation Reduces Aggression, Mating Behavior in Flies, Penn Study Finds

Whether you're a human, a mouse, or even a fruitfly, losing sleep is a bad thing, leading to physiological effects and behavioral changes. One example that has been studied for many years is a link between sleep loss and aggression. But it can be difficult to distinguish sleep loss effects from stress responses, especially in rodent or human models.

Karen Kreeger

Penn Scientists Find That Flow Means "Go" for Proper Lymph System Development

Penn Scientists Find That Flow Means "Go" for Proper Lymph System Development

The lymphatic system provides a slow flow of fluid from our organs and tissues into the bloodstream. It returns fluid and proteins that leak from blood vessels, provides passage for immune and inflammatory cells from the tissues to the blood, and hosts key niches for immune cells. How this system develops hasn’t been well understood, but now researchers from the Perelman School of Medicine at the University of Pennsylvania have found from experiments in mice that the early flow of lymph fluid is a critical factor in the development of mature lymphatic vessels.

Karen Kreeger

A Bash Between Friends

A Bash Between Friends

It wasn’t long ago that Maria Soltero-Rivera learned an important lesson: “Different is good.” “We’ve been working so hard doing this, and this little girl puts into a few simple words exactly what we’ve been trying to communicate to everyone,” Soltero-Rivera says. “You just learn so much from these kids.”

Lauren Hertzler

Penn Study Finds Link between Physician Training and Brand Name Prescribing

Penn Study Finds Link between Physician Training and Brand Name Prescribing

Physicians in training are twice as likely to order a costly brand-name statin (used to lower blood cholesterol levels) when supervised by senior physicians who prefer those medications in their own practice, according to a new study led by researchers at the

Anna Duerr

Researchers at Penn Develop Scar-like Culture Systems to Understand and Treat Fibrosis

Researchers at Penn Develop Scar-like Culture Systems to Understand and Treat Fibrosis

A scar might be a reminder of an accident or surgery, but the fibrous tissue that makes up a scar also forms after a heart attack and arises in solid tumors as well as in chronic diseases such as liver cirrhosis and muscular dystrophy. Implanted medical devices and materials are similarly surrounded by fibrous capsules that impede their function.  

Evan Lerner

Vision-Restoring Gene Therapy Also Strengthens Visual Processing Pathways in Brain, According to Penn Study

Vision-Restoring Gene Therapy Also Strengthens Visual Processing Pathways in Brain, According to Penn Study

Since 2007, clinical trials using gene therapy have resulted in often-dramatic sight restoration for dozens of children and adults who were otherwise doomed to blindness. Now, researchers from the Perelman School of Medicine at the University of Pennsylvania and The Children’s Hospital of Philadelphia (CHOP), have found evidence that this sight restoration leads to strengthening of visual pathways in the brain, published this week in Science Translational Medicine.

Karen Kreeger

Hydraulic Fracturing Linked to Increases in Hospitalization Rates in the Marcellus Shale Region, According to Penn Study

Hydraulic Fracturing Linked to Increases in Hospitalization Rates in the Marcellus Shale Region, According to Penn Study

Hospitalizations for heart conditions, neurological illness, and other conditions were higher among people who live near unconventional gas and oil drilling (hydraulic fracturing), according to new research from the University of Pennsylvania and Columbia University published this week in PLOS ONE.

Karen Kreeger

Penn Vet Team Shows a Protein Modification Determines Enzyme’s Fate

Penn Vet Team Shows a Protein Modification Determines Enzyme’s Fate

The human genome encodes roughly 20,000 genes, only a few thousand more than fruit flies. The complexity of the human body, therefore, comes from far more than just the sequence of nucleotides that comprise our DNA, it arises from modifications that occur at the level of gene, RNA and protein.

Katherine Unger Baillie