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Activating Pathway Could Restart Hair Growth in Dormant Hair Follicles, Penn Study Suggests

Activating Pathway Could Restart Hair Growth in Dormant Hair Follicles, Penn Study Suggests

A pathway known for its role in regulating adult stem cells has been shown to be important for hair follicle proliferation, but contrary to previous studies, is not required within hair follicle stem cells for their survival, according to researchers with the Perelman School of Medicine at the University of Pennsylvania.

Kim Menard

Penn Medicine: Brain Connectivity Study Reveals Striking Differences Between Men and Women

Penn Medicine: Brain Connectivity Study Reveals Striking Differences Between Men and Women

A new brain connectivity study from Penn Medicine published today in the Proceedings of National Academy of Sciences found striking differences in the neural wiring of men and women that’s lending credence to some commonly-held beliefs about their behavior.

Steve Graff

Five Penn Faculty Earn Distinction as AAAS Fellows

Five Penn Faculty Earn Distinction as AAAS Fellows

Five faculty members from the University of Pennsylvania have been named fellows of the American Association for the Advancement of Science.

Katherine Unger Baillie , Karen Kreeger

Researchers at Penn Uncover Mechanism Behind Blood Stem Cells’ Longevity

Researchers at Penn Uncover Mechanism Behind Blood Stem Cells’ Longevity

The blood stem cells that live in bone marrow are at the top of a complex family tree. Such stem cells split and divide down various pathways that ultimately produce red cells, white cells and platelets.

Evan Lerner

Penn Medicine: Paths Not Taken: Notch Signaling Pathway Keeps Immature T Cells on the Right Track

Penn Medicine: Paths Not Taken: Notch Signaling Pathway Keeps Immature T Cells on the Right Track

The lab of Avinash Bhandoola, PhD, professor of Pathology and Laboratory Medicine, has studied the origins of T cells for many years. One protein called Notch, which has well-known roles in the development of multiple tissues, plays an essential role in triggering T-cell development.

Karen Kreeger

Epigenetic Changes May Explain Chronic Kidney Disease, Penn Study Shows

Epigenetic Changes May Explain Chronic Kidney Disease, Penn Study Shows

The research of physician-scientist Katalin Susztak, MD, PhD, associate professor of Medicine in the Renal Electrolyte and Hypertension Division, at the Perelman School of Medicine, University of Pennsylvania, strives to understand the molecular roots an

Karen Kreeger

Penn Medicine: Targets of Anticancer Drugs Have Broader Functions than What Their Name Suggests

Penn Medicine: Targets of Anticancer Drugs Have Broader Functions than What Their Name Suggests

Drugs that inhibit the activity of enzymes called histone deacetylases (HDACs) are being widely developed for treating cancer and other diseases, with two already on the market. Researchers at the Perelman School of Medicine, University of Pennsylvania, show that a major HDAC still functions in mice even when its enzyme activity is abolished, suggesting that the beneficial effects of HDAC inhibitors may not actually be through inhibiting HDAC activity, and thus warranting the reassessment of the molecular targets of this class of drugs.

Karen Kreeger