Perelman School of Medicine

Old-fashioned alarm clock on top of an empty plate with a table setting

How our body’s internal clocks communicate may impact our overall health

Most cells contain molecular clocks, but the requirement of peripheral clocks for rhythmicity, and their effects on physiology, are not well understood. Now, a new study reveal the roles of the hepatocyte clock in cell communication and metabolism.

patient working out on a stationary bike

Increasing community impact through Penn Medicine CAREs grant program

Outside of hospitals and clinics, Penn Medicine physicians, nurses, staff, and students are serving their neighborhoods through volunteerism.

Bottle of liquid COVID-19 vaccination with a syringe lying against it in front of a row of vaccine bottles in the background.

Is the threat of COVID vaccine hesitancy getting enough attention?

The ultimate key to ending the coronavirus pandemic is developing an effective vaccine and administering it to the population. But a number of trends are converging in ways that may prevent the achievement of that population-wide herd immunity.

Two soldiers on a field carry a stretcher with a wounded soldier.

U.S. military has improved mortality since World War II, with some alarming exceptions

Although wound survivability has increased over the last 80 years, the U.S. military’s medical corps suffered some periods of backsliding during conflicts.

Illustration of brain with DNA double helix

Getting gene therapy to the brain

Using a large animal model of genetic brain disease, researchers led by John H. Wolfe of the School of Veterinary Medicine, Perelman School of Medicine, and Children’s Hospital of Philadelphia delivered an effective treatment across the blood-brain barrier to correct the whole brain.

‘Self-eating’ stem cell process may be the key to new regenerative therapies

A Penn study uncovers new roles of chaperone-mediated autophagy in how stem cells repair or regenerate damaged organs.

Screenshot of a video call with 13 people

Interning virtually

The Translational Research Internship Program, offered by the Perelman School of Medicine’s Institute for Translational Medicine and Therapeutics Education Programs, provides mentorship for undergraduates as they complete a translational research project.

Person in hospital bed with COVID-19 presses their hand against a glass window with a loved one on the other side.

Hospitalized COVID-19 patients have low risk of stroke

While researchers found that 2.4% of patients hospitalized for COVID-19 had an ischemic stroke—the most common type of stroke, a new study suggests this is likely due to existing risk factors, rather than COVID-19.

Two people in athletic gear walking on tree-lined path

Nature access requires attention when addressing community health needs

Nature is a tool to address deeply entrenched health disparities; health systems should work to increase nature access, as they have with other social determinants of health.

illustration of a microscopic gene and the isolated protein with the mutation.

Rare genetic mutation leaves people at higher risk for multiple cancers

Researchers find a new and previously undiscovered mutation in a particular gene associated with a higher risk of multiple kinds of cancer, and can lead to modified screenings for this particular gene protein.

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