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Deconstructing the mechanics of bone marrow disease
microscopic image of an immune cell labeled purple against a gray background

Acollaborative team developed an alginate-based hydrogel system that mimics the viscoelasticity of the natural extracellular matrix in bone marrow. By tweaking the balance between elastic and viscous properties in these artificial ECMs, they could recapitulate the viscoelasticity of healthy and scarred fibrotic bone marrow, and study the effects on human monocytes placed into these artificial ECMs. (Image: Adam Graham/Harvard CNS/Wyss Institute at Harvard University)

Deconstructing the mechanics of bone marrow disease

A new understanding of how mechanical features of bone marrow affect resident immune cells in a fibrotic cancer points to future therapeutic strategies for cancers and fibrotic diseases.

Katherine Unger Baillie

Shapeshifting microrobots can brush and floss teeth
Graphic shows how nanoparticle-based microrobots can remove dental plaque from teeth with their motion and the activity of hydrogen peroxide (H2O2) to kill microbes

Shapeshifting microrobots can brush and floss teeth

In a proof-of-concept study, researchers from the School of Dental Medicine and School of Engineering and Applied Science shows that a hands-free system could effectively automate the treatment and removal of tooth-decay-causing bacteria and dental plaque.

Katherine Unger Baillie

Penn Dental’s Penntorship connects with the West Philadelphia community
Two smiling women stand in blue medical scrubs on a sunny day.

Kylie Schlesinger (left) and Julie Berenblum (right) founded the Penntorship program to connect mentors from the Penn Dental school to students from West Philadelphia High School. (Image: Courtesy of Kylie Schlesinger and Julie Berenblum)

Penn Dental’s Penntorship connects with the West Philadelphia community

Amid the COVID lockdown, Penn Dental Medicine students Kylie Schlesinger and Julie Berenblum founded a mentorship program for high schoolers in West Philadelphia.

Luis Melecio-Zambrano

A $365 million development will expand the life sciences hub at Pennovation Works
Rendering depicting aerial view of new life sciences building on Pennovation Works campus

A $365 million development will expand the life sciences hub at Pennovation Works

Penn Senior Executive Vice President Craig Carnaroli speaks with Penn Today about the evolution of the research and manufacturing project, led by Longfellow Real Estate Developers, and its value for Penn and the region.

Katherine Unger Baillie

Urging caution but not panic on monkeypox
microscopic view of monkeypox virus

In the last few weeks, an outbreak of monkeypox, a relative of smallpox, has affected nearly 100 people across 12 countries.

  • Q&A

    • Urging caution but not panic on monkeypox

    While unfamiliar to many in the U.S., monkeypox and other poxviruses have been on the radar of researchers at the School of Dental Medicine and Perelman School of Medicine for decades.

    Katherine Unger Baillie

    Symposium highlights range and reach of Penn Global research
    Panelists sit on a stage at Perry World House, while another is on a Zoom screen behind them

    The 2022 Launch Symposium at Perry World House brought together faculty from eight of Penn’s 12 schools to share presentations on their projects that span the globe.

    Symposium highlights range and reach of Penn Global research

    The Penn Global Research and Engagement Grant is supporting 21 faculty-led projects that span research, capacity-building, and development efforts across Africa, Latin America and the Caribbean, India, China, and beyond.

    Kristen de Groot

    How one inflammatory disorder exacerbates another
    graphic of a person with both gum inflammation and arthritis in an elbow, showing the cells involved in the relationship between the two conditions

    How one inflammatory disorder exacerbates another

    Researchers from the School of Dental Medicine and colleagues from Dresden, Germany demonstrate that an association between conditions such as severe gum disease and arthritis is traceable to the bone marrow.

    Katherine Unger Baillie

    Creating global systems for evidence-informed oral health policy
    Dental faculty member Alonso Carrasco-Labra

    With a background in evidence-based medicine and dentistry, Alonso Carrasco-Labra brings unique skills and perspective to the School of Dental Medicine.

    (Image: Kevin Monko)

    Creating global systems for evidence-informed oral health policy

    Alonso Carrasco-Labra, who joined the School of Dental Medicine in 2021, is a leader in developing new policy and clinical guidelines across areas of medicine.

    Katherine Unger Baillie

    A serendipitous finding lends new insight into how atopic dermatitis develops
    In two panels labeled "control skin" and "AD skin" stained cells show how inflammation is present in patients with atopic dermatitis

    New findings in atopic dermatitis reveal an inflammatory cascade unfolding early in disease development, according to researchers from the School of Dental Medicine, the Perelman School of Medicine, and Oak Ridge National Laboratory. (Image: Courtesy of Kang Ko)

    A serendipitous finding lends new insight into how atopic dermatitis develops

    Research from the School of Dental Medicine, the Perelman School of Medicine, and Oak Ridge National Laboratory reveals a mechanism behind the inflammation that is a feature of the common skin disease.

    Katherine Unger Baillie

    Teledentistry, educational videos expanding services to persons with disabilities
    Dental patient in a wheelchair being pushed into the Penn Dental Medicine Personalized Care Suite.

    The Personalized Care Suite of Penn Dental Medicine’s Care Center for Persons with Disabilities. (Image: Penn Dental News)

    Teledentistry, educational videos expanding services to persons with disabilities

    Penn Dental Medicine is continuing to build upon its services to persons with disabilities through the development of a teledentistry assessment portal and a series of education videos.

    From Penn Dental Medicine