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Armoring CAR T cells to take on cancer
 3D visualization showing a reddish-blue tumor mass with internal vasculature, surrounded by blue CAR T cells and small extracellular vesicles against a dark background.

Wei Guo of the School of Arts & Sciences and colleagues from the Perelman School of Medicine, School of Veterinary Medicine, and School of Engineering and Applied Science have teamed up to uncover how solid tumors’ complicated microenvironments can manipulate cancer-fighting CAR T cells through extracellular vesicles, causing the engineered CAR T cells to commit fratricide—essentially turning against each other instead of attacking the cancer.

(Image: iStock / Marcin Klapczynski)

Armoring CAR T cells to take on cancer

Wei Guo of the School of Arts & Sciences and colleagues from the Perelman School of Medicine, School of Veterinary Medicine, and School of Engineering and Applied Science have uncovered how solid tumors manipulate cancer-fighting CAR T cells through extracellular vesicles, causing the engineered CAR T cells to commit fratricide—essentially turning against each other instead of attacking the cancer.

3 min. read

Five Penn faculty elected to the American Academy of Arts and Sciences
Top row: Dennis Discher, Michael Correa-Jones, and Cherie Kagan. Bottom row: Sophie Rosenfeld and Susan Weiss.

Top row: Dennis Discher, Michael Correa-Jones, and Cherie Kagan. Bottom row: Sophie Rosenfeld and Susan Weiss.

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Five Penn faculty elected to the American Academy of Arts and Sciences

Dennis E. Discher, Michael Jones-Correa, Cherie R. Kagan, Sophia Rosenfeld, and Susan R. Weiss are being recognized for their contributions to engineering, political science, history, and biology.

3 min. read

How Penn engineers are restoring historic Springfield Mills
Jason Pastor and another lab worker at Penn’s MEAM lab.

Jason Pastor (left) is a senior coordinator of instructional labs at the Department of Mechanical Engineering and Applied Mechanics (MEAM) at Penn Engineering.

(Image: Courtesy of Penn Engineering)

How Penn engineers are restoring historic Springfield Mills

The gristmill on Wissahickon Creek, which dates back to 1761, required repairs to its modern machinery upgrades. Volunteers at the Morris Arboretum & Gardens turned to MEAM’s Precision Manufacturing Lab at Penn Engineering for the design of precision components.

From Penn Engineering

2 min. read

From sewing to 3D printing: Taylor Caputo and the Engineering Studios at Penn’s Venture Lab
Taylor Caputo in Penn’s Venture Lab.

Taylor Caputo is a lecturer in mechanical engineering and applied mechanics and director of the Engineering Studios @ Venture Lab.

(Image: Courtesy of Penn Engineering Today)

From sewing to 3D printing: Taylor Caputo and the Engineering Studios at Penn’s Venture Lab

The lecturer in mechanical engineering and applied mechanics and director of the Engineering Studios @ Venture Lab helps students bring student visions for new products to life through laser cutters, 3D printers, and even sewing machines.

Ian Scheffler

2 min. read

Turning bicycles into an engineering study tool
Penn students riding bikes over a bridge in Amsterdam.

Students explored Amsterdam with a bike tour and even a bicycle scavenger hunt.

(Image: Elizabeth Feeney)

Turning bicycles into an engineering study tool

Penn students explore the Netherlands’ cycling infrastructure and learn about bicycle design principles in Dustyn Roberts’ popular Penn Global Seminar.

5 min. read

Exploring the governance of artificial intelligence
A speaker at the Perry World House AI Governance panel.

Wharton’s Kevin Werbach described the conference as a “reflection of the incredible work on AI policy and governance happening across the University.”

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Exploring the governance of artificial intelligence

Perry World House, the Wharton AI & Analytics Initiative, the Wharton Accountable AI Lab, the School of Engineering & Applied Science, and the Center for Technology, Innovation & Competition at Penn Carey Law recently hosted researchers from across the University of Pennsylvania for an in-depth dis

From Perry World House

2 min. read

Scientists unlock frogs’ antibacterial secrets to combat superbugs
A tree frog in Thailand.

The researchers theorized that frogs must have developed antibiotics to survive in their challenging environment.

Image: Michael Edward via Getty Images

Scientists unlock frogs’ antibacterial secrets to combat superbugs

The lab of César de la Fuente has created synthetic peptides, a class of antibiotics, derived from the secretions of a frog commonly found in South Asia.

Ian Scheffler

2 min. read

Penn Electric Racing’s latest racecar
Students unveil their latest self-made electric race car on College Green, just in front of Benjamin Franklin statue.

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Penn Electric Racing’s latest racecar

Penn Electric Racing, the student-led Formula Society of Automotive Engineers electric team, debuted its latest electric race car, REVX, on College Green on March 28. This marks the team's 10th custom-designed car since its founding in 2013 and its most sophisticated to date.

3 min. read