Bioengineering

More cancers may be treated with drugs than previously believed

Using a Penn-designed neural network called PocketMiner, a Penn Medicine research team has identified hidden protein pockets that can provide new opportunities for cancer drugs to bind to.

A potential strategy to improve T cell therapy in solid tumors

A new Penn Medicine preclinical study finds that a new simultaneous “knockout” of two inflammatory regulators boosted T cell expansion to attach solid tumors.

Neuroscience explains why Bill Gates’ weird reading trick is so effective

A study by Penn researchers working in physics, neuroscience, and bioengineering found that people instinctively seek patterns and similarities in the data they absorb.

Havana Syndrome is a mystery, but not of physics

Ken Foster of the School of Engineering and Applied Science says that microwaves can stimulate the cochlea and cause people to hear a clicking sound known as the Frey effect.

Pregnant person in hospital bed with IV drip in hand.

Targeted prenatal therapy addresses long-standing gap in health equity

Penn engineers have developed a successful delivery system of mRNA to placental cells to treat preeclampsia at its root.

Preeclampsia treated via protein replacement therapy in mice

A team led by Ph.D. student Kelsey Swingle in Michael Mitchell’s lab at the School of Engineering and Applied Science has developed an ionizable lipid nanoparticle formation that can deliver mRNA to placental cells to treat a serious pregnancy-related condition.

Go bury yourself: Engineers design wooden seed carriers that drill down in the soil when exposed to rainfall

Shu Yang of the School of Engineering and Applied Science and colleagues have developed a wooden seed carrier that can improve the germination rates of aerial seeding in areas that are difficult to access.

Go bury yourself: Engineers design wooden seed carriers that drill down in the soil when exposed to rainfall

New insights into the mechanisms of tumor growth

A team of researchers led by the School of Arts & Science’s Wei Guo characterize the molecular pathways that play a major role in tumorigenesis, findings that could lead to better diagnostic tools for cancer and new targeted therapies.

RNA lipid nanoparticle engineering stops liver fibrosis in its tracks

A successful lipid nanoparticles drug delivery system targets notoriously hard-to-target activated fibroblasts in the liver.

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More cancers may be treated with drugs than previously believed

A potential strategy to improve T cell therapy in solid tumors

Neuroscience explains why Bill Gates’ weird reading trick is so effective

Havana Syndrome is a mystery, but not of physics

Targeted prenatal therapy addresses long-standing gap in health equity

Preeclampsia treated via protein replacement therapy in mice

Go bury yourself: Engineers design wooden seed carriers that drill down in the soil when exposed to rainfall

Go bury yourself: Engineers design wooden seed carriers that drill down in the soil when exposed to rainfall

New insights into the mechanisms of tumor growth

RNA lipid nanoparticle engineering stops liver fibrosis in its tracks