Biology

Tcells surround a cancer cell to finish it off, but such interactions do not always end with the T cells victorious. Researchers from Penn detail how cancer cells can prompt T cells to ingest bits of cancer cell membrane, a process known as trogocytosis. The cancer may evade immune detection as a result. (Image: Alex Ritter, Jennifer Lippincott Schwartz and Gillian Griffiths, National Institutes of Health)

Through the Penn Undergraduate Research Mentoring program, undergraduates Julia Youngman and Eric Tao studied the mating songs of brown-headed cowbirds like those above in Penn’s “smart” aviary.

The researchers found that levels of phosphorylated HRS varied across tumors, negatively corresponding with the level of T cell infiltration in those areas. (Image: Guo lab/Nature Communications)

The Quad elm cut an imposing figure, shown here in the spring of 2021, before leaf out. The space will be replanted with three native white oaks at a later date. (Image: Eric Sucar/University Communications)

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hile free-swimming microrobots have been explored as a way to precisely deliver therapeutics within a blood vessel, they can disperse in the strong flows, failing to reach their target at high enough concentrations. In contrast, microrobots propelled along an artificial microtubule, developed by physicist Arnold Mathijssen and colleagues, can be transported precisely, even working against the current. (Image: Courtesy of Arnold Mathijssen/Nature Machine Intelligence)

Reginald Kwarteng is an undergraduate student researcher in the Wagner Lab. (Image: Wil Prall)

When the enzyme DOT1L is not functional, spermatogonial stem cells become exhausted, leading to a failure of sperm cell development. This crucial role for DOT1L places it in rarefied company as one of just a handful of known stem cell self-renewal factors, a Penn Vet team found. (Image: Courtesy of Jeremy Wang)

A group of bacteriophages, viruses that infect bacteria, imaged using transmission electron microscopy. New research sheds light on how bacteria fight off these invaders without triggering an autoimmune response. (Image: ZEISS Microscopy, CC BY-NC-ND 2.0)