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Genomic differences selected through evolution may offer clues as to why COVID-19 outcomes vary widely
two DNA double helixes next to an illustration of the SARS-CoV-2 virus

COVID-19’s hard-to-predict effects likely owe in part to genetic differences. A Penn-led study analyzing the genomes of a diverse set of populations globally points to genetic variants that may help explain some of the variability in disease severity.

Genomic differences selected through evolution may offer clues as to why COVID-19 outcomes vary widely

A team from the University of Pennsylvania analyzed genomic data from global populations, including thousands of ethnically diverse Africans, to identify genetic variants that may be associated with clinical COVID-19 outcomes.

Katherine Unger Baillie

COVID mortality age patterns changed significantly during pandemic
An empty hospital bed in a hospital room.

COVID mortality age patterns changed significantly during pandemic

Between March 2020 and October 2021, death rates from the virus decreased for those 80 and older and increased for those 25 to 54, results that held across racial and ethnic groups.

Michele W. Berger

DNA analysis finds links between severe COVID and other conditions
A medical worker in full personal protective gear holds up an x-ray of a chest and lungs

DNA analysis finds links between severe COVID and other conditions

Through analyzing human DNA samples in a large biobank, Penn Medicine researchers found associations between genetic variants with severe COVID and conditions involving blood clots and respiratory issues.

From Penn Medicine News

A Wharton initiative championing global change
Screen shot of virtual meeting with various people on camera and some off-camera.

The Zicklin Center for Business Ethics Research at the Wharton School, Penn, and its many partners issued a call for proposals for an initiative: Building Capacity to Combat COVID-19 in Africa: Ideas and Innovations from Young Entrepreneurs. (Image: Ideas for Action, The Wharton School)

  • Q&A

    • A Wharton initiative championing global change

    The Ideas for Action Wharton undergraduate student club is a joint initiative with the Zicklin Center for Business Ethics Research to engage youth around the world in developing solutions to global challenges.

    Dee Patel

    From a pandemic, scientific insights poised to impact more than just COVID-19
    emulsions of oil and water separated by a layer of nanoparticles.

    Bijels, or bicontinuous interfacially jammed emulsion gels, are structured emulsions of oil and water that are kept separated by a layer of nanoparticles. Penn Engineering researchers will develop a way of using them to manufacture mRNA-based therapeutics. (Image: Penn Engineering Today)

    From a pandemic, scientific insights poised to impact more than just COVID-19

    Pivoting to study SARS-CoV-2, many scientists on campus have launched new research projects that address the challenges of the pandemic but also prepare us to confront future challenges.

    Katherine Unger Baillie