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Brain tumor organoids accurately model patient response to CAR T cell therapy
Microscopic view of a glioblastoma organoid.

A patient-derived glioblastoma organoid treated with dual-target CAR-T cells. T cells (magenta) infiltrate the tumor organoid and kill tumor cells (blue; yellow indicates dying cells).

(Image: Yusha Sun and Xin Wang from the laboratories of Guo-li Ming and Hongjun Song)

Brain tumor organoids accurately model patient response to CAR T cell therapy

Lab-grown tumors respond to cell therapy the same as tumors in the patients’ brains, according to researchers at Penn Medicine.

Kelsey Geesler

2 min. read

Q&A: Dean Kumar and the ‘drone’ sightings
Picture of a drone flying lit nighttime cityscape

For more than a month, residents in New Jersey, parts of Pennsylvania, and New York have spotted unidentified flying objects, which local residents refer to as “drones,” hovering over neighborhoods, critical infrastructure and even restricted sites. To learn more about the mysterious flying objects, Penn Today spoke with local expert Dean Vijay Kumar of the School of Engineering and Applied Science.

(Image: Courtesy of iStock/Naypong)

  • Q&A

    • Q&A: Dean Kumar and the ‘drone’ sightings

    Penn Engineering Dean Vijay Kumar discusses the mysterious flying objects, or “drones,” hovering around parts of the East Coast.
    A study of scammer culture in popular media
    Engraved vintage drawing of fragments of a broken mirror with a reflection of a female face on female hands.

    Image: iStock/maystra

    A study of scammer culture in popular media

    Sarah Banet-Weiser and Kathryn Claire Higgins examine how the shows “Inventing Anna” and “The Dropout” reflect a post #MeToo society.

    Mark Cuban’s take on prescription drug pricing models
    Zeke Emanuel and Mark Cuban in discussion in front of an audience.

    Image: Courtesy of Penn LDI

    Mark Cuban’s take on prescription drug pricing models

    In late November, hundreds of students, researchers, faculty, and staff from Penn’s Wharton School Health Care Management attended a discussion between entrepreneur Mark Cuban and Ezekiel Emanuel.

    Hoag Levins

    A decade-plus legacy of Penn Arts & Sciences
    Steve Fluharty seated at a table with hands folded.

    Steven J. Fluharty, Thomas S. Gates, Jr. Professor of Psychology, Pharmacology, and Neuroscience and dean of the School of Arts & Sciences.

    (Image: Lisa J. Godfrey)

    A decade-plus legacy of Penn Arts & Sciences

    In recognition of the end of Steven J. Fluharty’s term as dean of the School of Arts & Sciences, a look at the School’s growth and innovation over 12 years.

    Loraine Terrell , Michele W. Berger

    The future of finance
    A hand holding a crystal ball with finance charts and graphs inside.

    Image: iStock/SergeyNivens

    The future of finance

    Hosted by Wharton finance professor Itay Goldstein, this four-part podcast series takes a deep dive into the cutting-edge insights and pioneering perspectives of innovation experts in the finance industry.

    From Knowledge at Wharton

    The quest to find actionable data for policymakers in developing countries
    Cocoa farming in Ghana.

    In Ghana, a team led by associate professor of practice Heather Huntington is working with many partners to support “deforestation-free cocoa,” which could reduce greenhouse gas emissions, increase carbon sequestration, and help cocoa farmers up their productivity and resilience.

    (Image: Courtesy of Heather Huntington)

    The quest to find actionable data for policymakers in developing countries

    A collaboration between the Penn Development Research Initiative and the DevLab@Penn is on the ground in developing nations to generate better evidence that can influence real-world decisions.

    From Omnia

    Mapping molecular arrangements to pave the way for better catalytic systems
    Bright spots represent individual catalyst molecules captured under cryogenic conditions to prevent clustering.

    Eric Stach of the School of Engineering and Applied Science and colleagues used neural networks to better identify the characteristics of catalysts that drive the creation of liquid fuels from sunlight. Shown here: The arrangement of a catalyst molecule, as observed under cryogenic conditions. The bright spots represent individual or small groups of molecules immobilized on a surface and the cryogenic temperature helps minimize clustering caused by the electron beam during imaging, allowing scientists to study the molecule’s distribution more accurately.

    (Image: Sungho Jeon)

    Mapping molecular arrangements to pave the way for better catalytic systems

    The Stach Group in Penn Engineering led a collaborative team identifying how chemical catalysts drive the creation of liquid fuels from sunlight, paving the way for more efficient removal of greenhouse gases from the atmosphere.
    The other emissions coming from cars
    A gloved mechanic holds a new tire.

    Image: iStock/dangrytsku

    The other emissions coming from cars

    Tiny tire particles discharge into the environment every time a vehicle brakes, accelerates, or rounds a curve. In a UN brief, geochemist Reto Gieré and colleagues aim to educate the world about this lesser-known environmental obstacle.

    Michele W. Berger

    Using data to make city planning more safe and accessible
    Xiaoxia Dong.

    Xiaoxia “Summer” Dong is an assistant professor of city and regional planning in the Weitzman School.

    nocred

    Using data to make city planning more safe and accessible

    Weitzman School of Design’s Xiaoxia ‘Summer’ Dong focuses on the travel behavior and mode choice impacts of driverless cars.

    From the Weitzman School of Design

    1 min. read