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A molecular ‘atlas’ of animal development
An abstract depiction of data features an elongated shape with various projections in pixels of different colors.

Each cell of a developing nematode worm embryo is catalogued at the molecular level in a new paper out in Science. In this visualization of the dataset, each dot represents a single cell, its color represents the age of the embryo it came from (orange=early, green=mid, blue/red=late), and the dots are arranged so that cells with similar transcriptomes are near each other. Visualized this way, the data form various thin “trajectories” that correspond to tissues and individual cell types. (Image: Cole Trapnell)

A molecular ‘atlas’ of animal development

Scientists have studied the nematode worm Caenorhabditis elegans for decades, making essential contributions to basic science. In the latest milestone, a team uses cutting-edge technology to individually profile the genes expressed in more than 80,000 cells in a developing C. elegans embryo.

Katherine Unger Baillie

Cardiac genetic mutation may not always predict heart disease
points of light representing the human torso and the human heart signifying cardiovascular health

Cardiac genetic mutation may not always predict heart disease

Researchers at Penn Medicine and Geisinger find only 5% of patients with a mutation of the TTN gene have dilated cardiomyopathy, despite changes in heart function.

Penn Today Staff

New spinal muscle atrophy treatment gains approval
genetic sequence

New spinal muscle atrophy treatment gains approval

Zolgensma is based on a delivery system discovered by a Penn gene therapy pioneer, marking a new milestone in treating the rare disease.

Penn Today Staff

Researchers use gene editing with CRISPR to treat lethal lung diseases before birth
CRISPR-edited lung cells (green) with EGFP fluorescent protein.

CRISPR-edited lung cells (green) with EGFP fluorescent protein. Many, but not all, are alveolar type 2 cells, the target cell type for STM study. (Image: Ed Morrisey, Penn Medicine)

Researchers use gene editing with CRISPR to treat lethal lung diseases before birth

Using CRISPR gene editing, a team from Penn Medicine and Children’s Hospital of Philadelphia have thwarted a lethal lung disease, in which a harmful mutation causes death within hours after birth.

Penn Today Staff

Three from Penn elected to the American Academy of Arts and Sciences
Anita Allen, Daniel Rader, and Zeid Ra'ad Al Hussein

Penn's Anita L. Allen, Daniel J. Rader, and Zeid Ra'ad Al Hussein are among more than 200 newly elected members of the American Academy of Arts and Sciences.

Three from Penn elected to the American Academy of Arts and Sciences

Vice Provost for Faculty Anita Allen of the Law School and the School of Arts and Sciences, Daniel Rader of the Perelman School of Medicine, and Zeid Ra’ad Al Hussein of Perry World House join a group recognized for their world-class leadership and expertise.

Katherine Unger Baillie

Unlocking the female bias in lupus
Microscopic images of cells are blue with diffuse splotches of pink on each cell.

Unlocking the female bias in lupus

The majority of lupus patients are female, and new findings from Montserrat Anguera of the School of Veterinary Medicine and colleagues shed light on why. The research suggests that female lupus patients don’t fully silence their second X chromosome in T cells, leading to an immune response gone awry.

Katherine Unger Baillie