Immunology | Penn Today

Penn immunotherapy pioneer Carl June shares prize from Israeli foundation that also honors Fauci

Carl June of the Perelman School of Medicine was awarded a Dan David prize for his contributions to immunotherapy.

Illustration of a T cell releasing signaling molecules, IL-4, IL-5, IL-6, IL-10, and IL-13

Charting a path forward with unifying definition of cytokine storm

Penn Medicine researchers have developed a unifying definition of “cytokine storm” to provide a framework to assess and treat patients whose immune systems have gone rogue.

Microscopic view of antibodies destroying an infected cell by a virus.

Novel Dual CAR T cell immunotherapy promising for targeting the HIV reservoir

A new alteration to the way T cells are engineered has significant implications for using engineered T cells to fight both HIV and cancer.

Microscopic view of plasma cells and antibodies.

A potential cause of CAR T side effects, and a path forward

Single cell sequencing aided researchers in identifying a previously undiscovered molecule in the brain.

A woman may have been cured of HIV without medical treatment

Una O’Doherty of the Perelman School of Medicine commented on a study that appeared to fully suppress HIV without using drugs. “It’s certainly encouraging but speculative,” she said. “I need to see more before I would say, ‘Oh, she’s cured.’”

Avery Posey in a medical lab wearing a white coat.

Avery Posey’s cancer research takes high risks for big rewards

The assistant professor of systems pharmacology and translational therapeutics, who studied with Carl June as a postdoctoral fellow, combines his two research passions—gene therapy and investigating ‘little known’ biology—in the pursuit of new knowledge.

Q&A

Navigating cytokine storms

Pairing their expertise, Nilam Mangalmurti of the Perelman School of Medicine and Christopher Hunter of the School of Veterinary Medicine have been working to understand the protective and harmful aspects of the immune response, including in COVID-19.

Decades-old Soviet studies hint at coronavirus strategy

Paul Offit of the Perelman School of Medicine said the benefits of a repurposed vaccines are limited. “We are much better off with a vaccine that induces specific immunity,” he said.

Two people side by side in different images. In the one on the left, the person stands in an office and a blue suit, hands crossed low in front. In the one on the right is a person in a tie and white coat that reads, "Carl H. June, M.D. Abramson Cancer Center"

Kathleen Hall Jamieson, Carl June elected to National Academy of Sciences

The researchers, from the Annenberg Public Policy Center and the Perelman School of Medicine, join a class of honored scholars recognized for their unique and ongoing contributions to original research.

Fluorescent microscopic image shows mammary gland cells

Tailoring treatment for triple-negative breast cancer

Research led by the School of Veterinary Medicine’s Rumela Chakrabarti identified a molecular pathway responsible for the disease’s progression and spread.

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