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Immunology
A potential strategy to improve T cell therapy in solid tumors
A potential strategy to improve T cell therapy in solid tumors
A new Penn Medicine preclinical study finds that a new simultaneous “knockout” of two inflammatory regulators boosted T cell expansion to attach solid tumors.
Harnessing an innate protection against Ebola
Harnessing an innate protection against Ebola
School of Veterinary Medicine researchers have identified a cellular pathway that keeps Ebola virus from exiting human cells, with implications for developing new antivirals.
Five things to know about this year’s ‘tripledemic’
Five things to know about this year’s ‘tripledemic’
The Perelman School of Medicine’s E. John Wherry and Scott Hensley discuss the season’s confluence of COVID-19, influenza, and RSV and how our bodies are responding.
CAR T cell therapy may eliminate tumor cells missed by surgery
CAR T cell therapy may eliminate tumor cells missed by surgery
The results of a study led by Penn Medicine’s Carl June greenlights preclinical trials for the application of CAR T therapy in gel form to surgical wounds following partial tumor removal to eliminate residual tumor cells.
Advances in cancer research
Advances in cancer research
Recent research shows promise in a novel CAR T therapy after cancer relapse, and a novel treatment for multiple myeloma.
CAR T cell therapy reaches beyond cancer
CAR T cell therapy reaches beyond cancer
Penn Medicine researchers laud the early results for CAR T therapy in lupus patients, which point to broader horizons for the use of personalized cellular therapies.
NIH-funded canine immunotherapy data center charts a path toward transformative therapies
NIH-funded canine immunotherapy data center charts a path toward transformative therapies
With support recently granted for five more years, Nicola Mason of the School of Veterinary Medicine and Qi Long of the Perelman School of Medicine hope their work leads to new insights in cancer care for people as well as pets.
$50M gift to accelerate Colton Center for Autoimmunity at Penn Medicine
$50M gift to accelerate Colton Center for Autoimmunity at Penn Medicine
The center for autoimmune research brings together star faculty, powering the next generation of autoimmune disease advances.
Penn Medicine CAR T therapy expert Carl June receives 2022 Keio Medical Science Prize
Penn Medicine CAR T therapy expert Carl June receives 2022 Keio Medical Science Prize
The award from Japan’s oldest private university honors outstanding contributions to medicine and life sciences.
T cells that ‘nibble’ tumors unwittingly help cancer evade the immune response
T cells that ‘nibble’ tumors unwittingly help cancer evade the immune response
Blocking this process, known as trogocytosis, improved the ability of a CAR T cell therapy to treat cancer in mice, according to research led by School of Veterinary Medicine scientists.
In the News
ScienceFriday.com
CAR-T cell therapies show promise for autoimmune diseases
Daniel Baker, a Ph.D. student in Carl June’s lab at the Perelman School of Medicine, discusses the results of a study on donor CAR-T cell therapy.
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Live Science
‘Any protein you can imagine, it can deliver’: AI will help discover the next breakthrough in RNA, says Nobel Prize winner Dr. Drew Weissman
Drew Weissman of the Perelman School of Medicine is launching a new RNA research hub that will use artificial intelligence to help train scientists and guide their experiments.
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Nature
Is bird flu spreading among people? Data gaps leave researchers in the dark
Scott Hensley of the Perelman School of Medicine says that there are fears of bird flu spreading at low levels through humans in a Missouri community.
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Forbes
Carl June: 2024 will be seen as a breakthrough year for brain cancer
Carl June of the Perelman School of Medicine shares five insights on using CAR T cell therapy to combat cancer, featuring remarks from Bruce Levine.
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Women’s Health
How to make yourself sneeze and find relief fast, according to doctors
John V. Bosso of the Perelman School of Medicine says that sneezing helps clear the nose of irritants, dirt, allergens, viruses, and bacteria.
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The New York Times
A bird-flu pandemic in people? Here’s what it might look like
Scott Hensley of the Perelman School of Medicine says that the bird flu virus would have to change significantly to be able to bind effectively to human cells.
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