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Immunology
Monkeypox: What is known and unknown
Monkeypox: What is known and unknown
The current outbreak of monkeypox is showing no sign of slowing. Stuart Isaacs of the Perelman School of Medicine, an expert on poxviruses, sheds light on the disease, its prevention and treatment, and what to watch for this fall.
Cancer cells selectively load ‘drones’ to keep T cells from infiltrating tumors
Cancer cells selectively load ‘drones’ to keep T cells from infiltrating tumors
Biologist Wei Guo and colleagues elucidate the process of sorting and loading cargo for these biological drones with implications for a more targeted and effective use of checkpoint inhibitor drugs in cancer treatment.
Deconstructing the mechanics of bone marrow disease
Deconstructing the mechanics of bone marrow disease
A new understanding of how mechanical features of bone marrow affect resident immune cells in a fibrotic cancer points to future therapeutic strategies for cancers and fibrotic diseases.
One protein’s role in genomic intermingling and T cell development
One protein’s role in genomic intermingling and T cell development
The findings, from a team led by Golnaz Vahedi of Penn Medicine, could have implications for T-cell based immunotherapies for cancer and other conditions.
Regulating the regulators of the immune system
Regulating the regulators of the immune system
Research led by School of Veterinary Medicine scientists reveals a new layer of complexity with which the immune system finds a balance between controlling pathogens and protecting healthy tissue.
CAR T cells suppress GI solid tumor cells without toxicity to healthy tissue
CAR T cells suppress GI solid tumor cells without toxicity to healthy tissue
New research finds that CAR T cells can eliminate solid tumors, but do not damage healthy, normal tissues that also express a tumor antigen, because the tumor antigen is sequestered and hidden between the normal cells.
Decade-long remission after CAR T cell therapy
Decade-long remission after CAR T cell therapy
Two patients represent longest-known CAR T cell response to date, providing insight into treatment effect and outcomes.
First-in-human trial with CAR macrophages shows promise targeting solid tumors
First-in-human trial with CAR macrophages shows promise targeting solid tumors
A new Penn study demonstrates that engineered macrophages, which can be targeted to tumors, may be a possible new immune-based treatment of some cancers.
New insights into T-cell exhaustion could improve cancer immunotherapies
New insights into T-cell exhaustion could improve cancer immunotherapies
A new Penn Medicine study finds that suppressing key exhaustion genes may allow CAR T cell treatments to be used much more effectively against pancreatic and other solid cancers.
A new class of CAR T cells targets previously untargetable cancer drivers
A new class of CAR T cells targets previously untargetable cancer drivers
Focusing on neuroblastoma, researchers from the Perelman School of Medicine and Children’s Hospital of Philadelphia have harnessed the immune system to destroy tumors.
In the News
Time
Scientists are racing to develop a new bird flu vaccine
Drew Weissman and Scott Hensley of the Perelman School of Medicine are testing a vaccine to prevent a strain of H5N1 bird flu in chickens and cattle.
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Fortune
California declares a state of emergency as a new severe bird flu case was discovered. What it means for the rest of the country
Scott Hensley of the Perelman School of Medicine says the latest H5N1 bird flu strain might have a greater potential to adapt and cause severe disease in humans.
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HealthDay
Keto diet supplement could boost a cancer treatment's effectiveness
A study by Perelman School of Medicine student Puneeth Guruprasad and postdoc Shan Liu suggests that a component of the keto diet could boost CAR T cell therapy to help treat cancer.
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The Scientist
A beneficial bacterium helps wounds heal
Research by Ellen White of the Perelman School of Medicine and colleagues in Elizabeth Grice’s lab suggests that a bacterium found in chronic wounds can aid healing.
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Stat
Scientists confront a mystery: Why have U.S. bird flu cases been so mild?
Scott Hensley of the Perelman School of Medicine says that one or two mutations can greatly change the pathogenicity profile of current bird flu viruses.
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ScienceFriday.com
CAR-T cell therapies show promise for autoimmune diseases
Daniel Baker, a Ph.D. student in Carl June’s lab at the Perelman School of Medicine, discusses the results of a study on donor CAR-T cell therapy.
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