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Immunology
Penn nanoparticles are less toxic to T cells engineered for cancer immunotherapy
Penn nanoparticles are less toxic to T cells engineered for cancer immunotherapy
By using messenger RNA across the T cell’s membrane via a nanoparticle instead of a DNA-rewriting virus on extracted T cells, CAR T treatments could have fewer side effects.
These overlooked global diseases take a turn under the microscope
These overlooked global diseases take a turn under the microscope
Faculty at the School of Veterinary Medicine target neglected tropical diseases with advanced science, cross-disciplinary collaborations, and work in the lab and the field.
Positive results in first-in-U.S. trial of CRISPR-edited immune cells
Positive results in first-in-U.S. trial of CRISPR-edited immune cells
Genetically editing a cancer patient’s immune cells using CRISPR/Cas9 technology, then infusing those cells back into the patient appears safe and feasible based on early data from the first-ever clinical trial to test the approach in humans in the United States.
To monitor cancer therapy, researchers tag CAR T cells with imaging markers
To monitor cancer therapy, researchers tag CAR T cells with imaging markers
With CAR T cell therapy, a patient’s own immune cells are genetically modified and inserted back into the body to find and kill cancer. Now scientists have now discovered a new way to track CAR T cells in the body.
Researchers unravel the early makings of an exhausted T cell
Researchers unravel the early makings of an exhausted T cell
Knowing which T cells will lose the battle against cancer earlier could inform treatments and the development of new immunotherapies.
Algorithm personalizes which cancer mutations are best targets for immunotherapy
Algorithm personalizes which cancer mutations are best targets for immunotherapy
A new model developed by researchers in the Abramson Cancer Center hand-picks cancer cells to target for more effective, customized cancer vaccines.
CAR T cell therapy may be harnessed to treat heart disease
CAR T cell therapy may be harnessed to treat heart disease
Penn Med researchers used genetically modified T cells to improve heart function in an animal model after cardiac injury, a step forward in expanding the use of the technology to treating, or even reversing, heart failure.
Balance of ‘stop’ and ‘go’ signaling could be key to cancer immunotherapy
Balance of ‘stop’ and ‘go’ signaling could be key to cancer immunotherapy
A Penn study shows potential of the interferon pathway as a biomarker to help predict which patients are likely to respond to immunotherapies.
Elderly patients with metastatic renal cell carcinoma benefit from targeted therapies
Elderly patients with metastatic renal cell carcinoma benefit from targeted therapies
A Penn study of Medicare patients who are often underrepresented in medical trials finds overall survival benefits from treatment with targeted therapies.
How to reinvigorate exhausted immune cells to stop cancer
How to reinvigorate exhausted immune cells to stop cancer
A Penn study has identified a protein called TOX that regulates exhausted T-cells, and could be a key to new immunotherapies.
In the News
ScienceFriday.com
CAR-T cell therapies show promise for autoimmune diseases
Daniel Baker, a Ph.D. student in Carl June’s lab at the Perelman School of Medicine, discusses the results of a study on donor CAR-T cell therapy.
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Live Science
‘Any protein you can imagine, it can deliver’: AI will help discover the next breakthrough in RNA, says Nobel Prize winner Dr. Drew Weissman
Drew Weissman of the Perelman School of Medicine is launching a new RNA research hub that will use artificial intelligence to help train scientists and guide their experiments.
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Nature
Is bird flu spreading among people? Data gaps leave researchers in the dark
Scott Hensley of the Perelman School of Medicine says that there are fears of bird flu spreading at low levels through humans in a Missouri community.
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Forbes
Carl June: 2024 will be seen as a breakthrough year for brain cancer
Carl June of the Perelman School of Medicine shares five insights on using CAR T cell therapy to combat cancer, featuring remarks from Bruce Levine.
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Women’s Health
How to make yourself sneeze and find relief fast, according to doctors
John V. Bosso of the Perelman School of Medicine says that sneezing helps clear the nose of irritants, dirt, allergens, viruses, and bacteria.
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The New York Times
A bird-flu pandemic in people? Here’s what it might look like
Scott Hensley of the Perelman School of Medicine says that the bird flu virus would have to change significantly to be able to bind effectively to human cells.
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