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Penn Medicine, CHOP team awarded Breakthrough Prize for developing gene therapy for inherited blindness
Jean Bennett and Albert Maguire

Physician-scientists Jean Bennett and Al Maguire (right and left, respectively, pictured in their home), and Katherine High received the 2026 Breakthrough Prize in Life Sciences for their trailblazing work on the first FDA-approved gene therapy for an inherited condition, which dramatically improves sight in people with a form of blindness called Leber congenital amaurosis.

(Image: Peggy Peterson)

Penn Medicine, CHOP team awarded Breakthrough Prize for developing gene therapy for inherited blindness

Jean Bennett, Albert Maguire, and Katherine High have been honored for their trailblazing work on the first FDA-approved gene therapy for an inherited condition.

From Penn Medicine News , Frank Otto

2 min. read

How estrogen in the brain impacts stress and trauma response
The human hippocampus.

Image: libre de droit via Getty Images

How estrogen in the brain impacts stress and trauma response

New research from Penn Medicine reveals how estrogen levels in the brain influence vulnerability to stress-related memory problems, helping explain sex differences in PTSD risk.

Eric Horvath

2 min. read

Shujie Yang harnesses sound to build the next generation of microrobotic medicine
Shujie Yang

Shujie Yang is at the frontier of single-cell acoustic manipulation, an emerging field that blends physics, mechanobiology, and medicine.

(Image: Courtesy of Penn Engineering)

Shujie Yang harnesses sound to build the next generation of microrobotic medicine

Yang’s lab at Penn Engineering uses precisely-controlled ultrasound waves to develop microscale tools that can manipulate cells, viruses, and soft materials without physical contact.

Melissa Pappas

2 min. read

A kidney for her mom, a marathon for herself
Jen Brady (right) and her mom seated at a kitchen table.

Six months after donating a kidney to her mother through Penn Medicine’s Center for Living Donation, Jen Brady (right) ran her third Boston Marathon.

(Image: Courtesy of Penn Medicine News)

A kidney for her mom, a marathon for herself

Working with the team at the Center for Living Donation, Penn Medicine’s benefits director Jen Brady felt confident enough to donate a kidney to her mother and run the Boston Marathon several months post-surgery.

From Penn Medicine News

2 min. read

Making older homes a safer haven for young families
Two members of a lead abatement team surveying a house under lead abatement treatment.

The Green & Healthy Homes team tests the home, identifying any hazardous paint, and potentially replacing the surface and/or paint while the family stays in a local hotel.

(Image: Courtesy of Penn Medicine News)

Making older homes a safer haven for young families

After five years, the Lead-Free Families initiative is proving the impact of a health system investing in safe homes.

From Penn Medicine News

Can AI manage an entire medical decision process?

Can AI manage an entire medical decision process?

A new Wharton study tests whether AI can handle realistic clinical decision-making, a dynamic process that requires managing a patient’s condition under time pressure.

From Knowledge at Wharton

2 min. read

Stress tested, testing stress: Novel organoid models how the adrenal gland develops
Michinori Mayama (left) is showing a culture dish to Kotaro Sasaki (right) in a lab.

Michinori Mayama (left) and Kotaro Sasaki (right). 

(Image: Courtesy of Kotaro Sasaki)

Stress tested, testing stress: Novel organoid models how the adrenal gland develops

Researchers led by Penn Vet’s Kotaro Sasaki and Michinori Mayama have developed an organoid system that faithfully mimics how the human adrenal gland develops and forms complex tissue structures, providing a powerful tool to study adrenal biology and laying the groundwork for regenerative therapies targeting adrenal diseases.

3 min. read