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mRNA Research

‘In vivo’ RNA-based gene editing model for blood disorders developed
Microscopic rendering of mRNA gene editing.

Image: iStock/Ozgu Arslan

‘In vivo’ RNA-based gene editing model for blood disorders developed

Researchers from Penn Medicine and The Children’s Hospital of Philadelphia show that gene editing tools can be delivered via lipid nanoparticles, which would reduce cost and increase access to cutting-edge gene therapies.

Alex Gardner

People with a conspiracy mindset resist childhood vaccination
A person with a child holds up a hand to stop a person approaching with a vaccine vial and syringe.

Image: iStock/Anna Rozhkova

People with a conspiracy mindset resist childhood vaccination

Research by Dan Romer and Kathleen Hall Jamieson of the Annenberg Public Policy Center explains the role that having a conspiracy mindset plays in adult reluctance to vaccinate children.

From the Annenberg Public Policy Center

Putting biomedical research advances within reach
A medical worker gives a person a Covid vaccine.

Image: Courtesy of Penn Medicine Magazine

Putting biomedical research advances within reach

Treatments and vaccines are only useful in the hands of the people who need them, and Penn Medicine is working toward better access and equity for biomedical innovations.

Karen L. Brooks for Penn Medicine Magazine

A vaccine for pancreatic cancer?
Deutsche Welle

A vaccine for pancreatic cancer?

Drew Weissman of the Perelman School of Medicine comments on the efficacy of a potential pancreatic cancer vaccine.

Pancreatic cancer vaccine shows promise in small initial trial
Scientific American

Pancreatic cancer vaccine shows promise in small initial trial

Drew Weissman of the Perelman School of Medicine is supportive of findings about a pancreatic cancer vaccine, though he says larger studies are needed to determine effectiveness.

Why Penn research powers many FDA-approved treatments
Aerial image of Penn Medicine staff in the atrium celebrating.

On August 30, 2017, faculty and staff at the Perelman Center for Advanced Medicine gathered for a “flash mob” celebration of the the FDA approval of a Penn Medicine-developed personalized cellular immune therapy.

(Image: Courtesy of Penn Medicine News)

Why Penn research powers many FDA-approved treatments

Since 2017, the FDA approved more than two dozen new therapies with roots at Penn Medicine—almost half of which are first-in-class for their indications.

Karen L. Brooks for Penn Medicine Magazine

New mRNA vaccine to fight 20 known subtypes of influenza
Four bottles of Influenza vaccine beside one medical syringe.

Image: Bernard Chantal for Adobe Stock

New mRNA vaccine to fight 20 known subtypes of influenza

Heading into clinical trials, the new research from Penn Medicine may serve as a general preventative measure against future flu pandemics.

From Penn Medicine News

Behind the scenes in the lab and the future of mRNA research
A gloved hand holding a small vial of Sars-CoV2 mRNA vaccine.

Behind the scenes in the lab and the future of mRNA research

Developing new vaccines and novel mRNA delivery methods, coupled with the satisfaction of mentoring and selfless dedication to medicine, inspire the work of scientists at the Weissman Lab.

Alex Gardner