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BEND lipids improve LNP mRNA delivery and gene editing
A gloved hand holding a beaker of lipids in a lab.

A sample of the new lipids, which improve the success rate of lipid nanoparticles delivering their contents.

(Image: Sylvia Zhang)

BEND lipids improve LNP mRNA delivery and gene editing

Penn Engineering researchers have developed a new class of lipids called branched endosomal disruptor (BEND) lipids to better deliver mRNA and gene-editing tools.

Ian Scheffler

New ways to modulate cell activity remotely
3D rendering of cells on a blue backdrop

Cells are dynamic, fast-changing, complex, tiny, and often hard-to-see in environments that don’t always behave in predictable ways when exposed to external stimuli. Now, researchers led by Lukasz Bugaj of the School of Engineering and Applied Science have found new ways to modulate cell activity remotely.

(Image: iStock/Maksim Tkachenko)

New ways to modulate cell activity remotely

Penn researchers use temperature to guide cellular behavior, promising better diagnostics and targeted therapies.
Violent language in film has increased

Violent language in film has increased

A new study from the Annenberg School for Communication finds that violent speech in movies is increasing over time, even in non-crime films.

From Annenberg School for Communication

1 min. read

Mapping molecular arrangements to pave the way for better catalytic systems
Bright spots represent individual catalyst molecules captured under cryogenic conditions to prevent clustering.

Eric Stach of the School of Engineering and Applied Science and colleagues used neural networks to better identify the characteristics of catalysts that drive the creation of liquid fuels from sunlight. Shown here: The arrangement of a catalyst molecule, as observed under cryogenic conditions. The bright spots represent individual or small groups of molecules immobilized on a surface and the cryogenic temperature helps minimize clustering caused by the electron beam during imaging, allowing scientists to study the molecule’s distribution more accurately.

(Image: Sungho Jeon)

Mapping molecular arrangements to pave the way for better catalytic systems

The Stach Group in Penn Engineering led a collaborative team identifying how chemical catalysts drive the creation of liquid fuels from sunlight, paving the way for more efficient removal of greenhouse gases from the atmosphere.
Is ‘bypassing’ a better way to battle misinformation?
Cartoon images of grownups in failed negotiations over a laptop.

Image: iStock/Visual Generation

Is ‘bypassing’ a better way to battle misinformation?

Bypassing involves offering accurate information that has an implication opposite to that of the misinformation. New research from APPC finds bypassing may be superior to correction in forming beliefs, but not in attitude about the delivered information.

From the Annenberg Public Policy Center