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An ‘illuminating’ design sheds light on cholesterol
A researcher scribbles an organic molecule

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An ‘illuminating’ design sheds light on cholesterol

High levels of cholesterol are linked to heart disease, stroke, and many other health problems. However, this complex and vital fatty, water insoluble molecule—a lipid—is found in every cell of the body and is not all bad news. It also regulates crucial processes that science has yet to map.

3 min. read

A serendipitous find leads to lifesaving discoveries
Fluorescent imaging of glioblastoma under a microscope.

Image: Kyosuke Shishikura

A serendipitous find leads to lifesaving discoveries

A Penn-led team has revealed a how hydralazine, one of the world’s oldest blood pressure drugs and a mainstay treatment for preeclampsia, works at the molecular level. In doing so, they made a surprising discovery—it can also halt the growth of aggressive brain tumors.

3 min. read

Nanoparticle blueprints reveal path to smarter medicines
Hannah Yamagata, Research Assistant Professor Kushol Gupta and postdoctoral fellow Marshall Padilla, holding 3D-printed models of nanoparticles in a lab.

(From left) Doctoral student Hannah Yamagata, research assistant professor Kushol Gupta, and postdoctoral fellow Marshall Padilla holding 3D-printed models of nanoparticles.

(Image: Bella Ciervo)

Nanoparticle blueprints reveal path to smarter medicines

New research involving Penn Engineering shows detailed variation in lipid nanoparticle size, shape, and internal structure, and finds that such factors correlate with how well they deliver therapeutic cargo to a particular destination.

Ian Scheffler

2 min. read

U.S. Army veteran connects service to research on empathy in ancient Greece
Malcolm Nelson stands in front of the Penn Museum.

Malcolm Nelson, a new Provost’s Postdoctoral Fellow in Penn’s Department of Classical Studies, draws on his U.S. Army experience in his research on empathy in ancient Greece.

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U.S. Army veteran connects service to research on empathy in ancient Greece

Serving in the Army from 2009 to 2012 informed the research of Malcolm Nelson, Provost’s Postdoctoral Fellow in classical studies, on empathy norms in ancient Greek culture.

2 min. read

A massive chunk of ice, a new laser, and new information on sea-level rise
A researcher walking through a glacier in Greenland.

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A massive chunk of ice, a new laser, and new information on sea-level rise

For nearly a decade, Leigh Stearns and collaborators aimed a laser scanner system at Greenland’s Helheim Glacier. Their long-running survey reveals that Helheim’s massive calving events don’t behave the way scientists once thought, reframing how ice loss contributes to sea-level rise.

5 min. read

New Katz Center fellowship amplifies study of antisemitism through classes, events, and community
Mendel Kranz leaning against bookshelves in a library setting

Mendel Kranz is the inaugural recipient of the Ross-Silk-Lowenstein Postdoctoral Fellowship in the Study of Contemporary Antisemitism

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New Katz Center fellowship amplifies study of antisemitism through classes, events, and community

Mendel Kranz, the inaugural recipient of the Ross-Silk-Lowenstein Postdoctoral Fellowship in the Study of Contemporary Antisemitism, elevates awareness and critical inquiry into antisemitism through research projects, classroom dialogue, and educational events.

4 min. read

Mapping the links between brain development and mental health
Sheet of a child’s brain scans.

A collaborative team led by Theodore D. Satterthwaite, Golia Shafiei, and Michael P. Milham has developed a large-scale, open data resource for mapping brain development and its associations with mental health.

(Image: fmajor via Getty Images)

Mapping the links between brain development and mental health

A new large-scale, open data resource from the Perelman School of Medicine and collaborators helps researchers link brain development with mental health disorders.

3 min. read

Tumor-on-a-chip offers insight into cancer-fighting cells in immunotherapy
Hand holding a microdevice

Penn engineers and collaborators have developed a transparent, micro-engineered device that houses a living, vascularized model of human lung cancer—a “tumor on a chip”—and show that the diabetes drug vildagliptin helps more CAR T cells break through the tumor’s defenses and attack it effectively.

(Image: Courtesy of Dan Huh)

Tumor-on-a-chip offers insight into cancer-fighting cells in immunotherapy

Penn engineers and collaborators have built a living tumor on a chip to expose how cancers block immune attacks, and how one existing drug could make immunotherapy like CAR T more effective against solid tumors.

3 min. read

National award and appointment for Penn Nursing’s David (Hyunmin) Yu

National award and appointment for Penn Nursing’s David (Hyunmin) Yu

The postdoctoral research fellow in Penn Nursing’s Center for Health Outcomes and Policy Research has been selected as one of this year’s STAT Wunderkinds, a national recognition that highlights standout early-career researchers who are not yet independent scientists but are already making extraordinary contributions to biomedical science.

National award and appointment for Penn Nursing’s David (Hyunmin) Yu

A summer in the tick trenches
A person in PPE holding blue painters tape covered in several ticks.

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A summer in the tick trenches

With the help of five Penn undergrads, biology professor Dustin Brisson’s research group collected 9,000 tick specimens this summer to understand how seasonal activity patterns of these arachnids affects human pathogens and what role a changing climate might play.

Kristina Linnea García

2 min. read