Health Sciences

As men age, their testosterone levels decrease, but prior studies of the effects of administering testosterone to older men have been inconclusive.

Physicians, scientists and leaders from the University of Pennsylvania’s Perelman School of Medicine and the global pharmaceutical company Novartis will gather Tuesday evening to unveil the Novartis-Penn Center for Advanced Cellular Therapeutics (CACT).

Financial incentives aimed at increasing physical activity were most effective when the rewards were put at risk of being lost, according to new research from the Perelman School of Medicine at the University of Pennsylvania.

When doctors diagnose a torn ligament, it’s usually because they can see ruptures in the ligament’s collagen fibers, visible on a variety of different scans. However, they also often treat patients with many of the symptoms of a tear, but whose ligaments don’t show this kind of damage.   

An estimated 30 percent of the world’s population is chronically infected with the parasite Toxoplasma gondii. Most people live with the infection without noticeable effect, but it can be life-threatening for people with suppressed immune systems, such as people on cancer therapies or who have HIV/AIDS.

The oral cavity is a complex landscape, cavernous and full of irregular structures. Using a two-dimensional X-ray to map its variations can only reveal so much. That’s why a technological revolution that has made three-dimensional imaging of the teeth and jaws easier and safer has ushered in a transformation of practice in the dental clinic.

Two University of Pennsylvania professors are coauthors, along with two other scholars, on a perspective piece published this week in the journal Science that calls for an end to the use of genetic concepts of race in biological research.

Abolishing the 24-hour clock by knocking out a key gene during development accelerates aging and shortens lifespan by two thirds in mice, but this effect is absent if the gene deletion is delayed until after birth, according to a new study published this week in Science Translational Medicine by scientists from the Perelman School of Medicine at the University of Pennsylvania.

For the first time, researchers have shown that an enzyme key to regulating gene expression -- and also an oncogene when mutated -- is critical for the expression of numerous inflammatory compounds that have been implicated in age-related increases in cancer and tissue degeneration, according to new research from the Perelman School of Medicine at the University of Pennsylvania. Inhibitors of the enzyme are being developed as a new anti-cancer target.