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Priming the immune system to attack cancer
scientific diagram shows how immune training of neutrophils in the bone marrow can produce ROS, or reactive oxygen species, to produce an anti-cancer response by the immune system

Priming the immune system to attack cancer

An international team, co-led by the School of Dental Medicine’s George Hajishengallis, showed how immune “training” transforms certain immune cells to target tumors.

Katherine Unger Baillie

New insights into autoimmune disease
Scientific diagram shows how protein called DEL-1 leads to a T cell expressing FOXP3

New insights into autoimmune disease

According to research by the School of Dental Medicine’s George Hajishengallis and colleagues, novel insights into a pathway that restrains the immune response opens up new avenues for treating inflammatory and autoimmune conditions.

Katherine Unger Baillie

Five Penn faculty elected to the National Academy of Medicine
five faculty headshots and the Penn shield

The National Academy of Medicine welcomed 100 new members in their class of 2020, including five from Penn: from top left: William Beltran, Ronald Paul DeMatteo, Matthew McHugh, Raina Merchant, and Hongjun Song.

Five Penn faculty elected to the National Academy of Medicine

Five faculty from Penn are among the newest members of the National Academy of Medicine: William Beltran of the School of Veterinary Medicine, Matthew McHugh of the School of Nursing, and Ronald DeMatteo, Raina Merchant, and Hongjun Song of the Perelman School of Medicine.

Katherine Unger Baillie

Crowd-sourcing optogenetics data to tackle neurological diseases
Two people in front of two computer monitors. The person moving the mouse is sitting. The other person stands watching.

Sébastien Tremblay (front), a postdoctoral fellow in the Platt Labs, works in a specialized field of neuroscience called optogenetics, which shows clinical promise for treating conditions like epilepsy. To foster the open exchange of information, Tremblay spearheaded a crowd-sourced, free database that includes data from 45 labs in nine countries. (Pre-pandemic image: Kevin Monko)

Crowd-sourcing optogenetics data to tackle neurological diseases

The specialized field of neuroscience, optogenetics, shows clinical promise for conditions like epilepsy and Parkinson’s. But before human trials can get fully underway, the field must better understand a crucial intermediate step, aided by 45 labs in nine countries sharing information.

Michele W. Berger

Tracking the working dogs of 9/11
Veterinarians and handlers with their search-and-rescue dogs

Cynthia Otto (center) cared for search-and-rescue dogs during their work at the 9/11 disaster site, later studying the impact of their service on their health. (Image: Courtesy of Cynthia Otto)

Tracking the working dogs of 9/11

A study of search and rescue dogs led by the School of Veterinary Medicine showed little difference in longevity or cause of death between dogs at the disaster site and dogs in a control group.

Katherine Unger Baillie

Seeking refuge in the climate emergency
kirbati trees and water line

Seeking refuge in the climate emergency

The Perry World House 2020 Global Shifts Colloquium looked at the need to address mass displacement and why climate change poses a national security threat.

Kristen de Groot, Kristina García

Climate Week offers something for ‘every member of the Penn community’
Abstract image of red earth and blue water with words Climate Week at Penn

A week’s worth of online events, aimed at engaging the entire Penn community, will examine the interplay of climate change, COVID, and social injustice.

Climate Week offers something for ‘every member of the Penn community’

With participation from schools, centers, and groups across the University and a focus on the interplay of the climate emergency with social justice issues and the global pandemic, Climate Week at Penn will run September 21-25. The week’s dozens of events will help participants learn about the climate crisis—and then act.

Katherine Unger Baillie

Progress toward a treatment for Krabbe disease
Sequence of 8 MRI images showing treated versus untreated brains from 16 to 52 weeks

Treating dogs with Krabbe disease, a rare and fatal condition that also affects infants, with a gene therapy targeted to the brain led to remarkable results in a study led by a team from the School of Veterinary Medicine. (Image: Courtesy of Charles Vite)

Progress toward a treatment for Krabbe disease

The inherited disease, which typically kills children before their second birthday, has no cure, but a School of Veterinary Medicine study in a canine model offers hope for an effective gene therapy with lasting results.

Katherine Unger Baillie

What would it take to make the Delaware ‘swimmable’?
delaware river with ben franklin bridge in background

What would it take to make the Delaware ‘swimmable’?

With funding from the William Penn Foundation, the Water Center at Penn is investigating questions of water quality, access, and equity.

Katherine Unger Baillie