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Targeting tumor supporting cells: Advancing CAR T success in pancreatic cancer
Pancreatic cancer cells.

Image: Nemes Laszlo/Science Photo Library via Getty Images

Targeting tumor supporting cells: Advancing CAR T success in pancreatic cancer

Research led by Penn Vet’s Ellen Puré has used lipid nanoparticles to generate CAR T cells directed at a type of tumor support cells—cancer-associated fibroblasts—melting away the protective barrier around pancreatic tumor cells and paving the way for a potentially safer, more accessible, and cost-effective method to treat solid tumors.

3 min. read

The big reveal: Penn Medicine’s Match Day 2026
Two Penn Med students and two others under a 2026 balloon at Penn’s 2026 Match Day.

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The big reveal: Penn Medicine’s Match Day 2026

The Perelman School of Medicine’s graduating class of 2026 celebrated Match Day on March 20, revealing the location of their residencies with a celebration among faculty, friends, and family.

1 min. read

A stiff defense: Rethinking gum disease
A section of healthy human gum tissue captured using an imaging technique called Second Harmonic Generation microscopy. In this sample, collagen fibers (shown in yellow), which give healthy gums their firm, resilient stiffness, are dense and well-organized—acting as a supportive scaffold for the surrounding cells (shown in teal).

A section of healthy human gum tissue captured using an imaging technique called Second Harmonic Generation microscopy. In this sample, collagen fibers (shown in yellow), which give healthy gums their firm, resilient stiffness, are dense and well-organized—acting as a supportive scaffold for the surrounding cells (shown in teal).

(Image: Hardik Makkar)

A stiff defense: Rethinking gum disease

Penn Dental Medicine’s Kyle H. Vining and Hardik Makkar take a biomaterials approach to understanding periodontal disease, using a hydrogel system to investigate how the physical properties of the gum tissue impact inflammation.
A topical cream may prevent or slow growth of some common skin cancers

A topical cream may prevent or slow growth of some common skin cancers

An experimental cream developed at Penn Medicine that blocks a specific enzyme may offer a precise, better‑tolerated path to prevent and treat cutaneous squamous cell carcinoma.

Alex Gardner

1 min. read

Penn experts propose a tobacco playbook for food policy
A tablet with biometric stats on a desk with fresh produce and legumes.

Image: ruizluquepaz via Getty Images

Penn experts propose a tobacco playbook for food policy

Drawing on public policies that have been successful with tobacco control, Penn’s Center for Food and Nutrition Policy outlines a stronger framework for regulating ultra-processed foods.

Eric Horvath

2 min. read

Who, What, Why: Katelyn Candido on improving surgical procedures and keeping health care human-first
Katelyn Candido sitting on a staircase, smiling and facing forward, wearing a white coat and blue scrubs in the Perelman School of Medicine

Katelyn Candido, a second-year medical student at PSOM and aspiring neurosurgeon, researches a novel tool’s utility for improving surgical precision.

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  • Who, What, Why

    • Who, What, Why: Katelyn Candido on improving surgical procedures and keeping health care human-first

    Second-year medical student Katelyn Candido shares insight into her research project on a promising tool for improving surgical precision and efficiency, and why she aims to drive equitable patient care through a career in neurosurgery.

    3 min. read

    First CRISPR-based platform to pinpoint leukemia drivers
    Rendering of a blood drop with a genetic DNA code inside.

    Image: Alena Butusava via Getty Images

    First CRISPR-based platform to pinpoint leukemia drivers

    The new toolkit, developed by Penn Medicine and Children’s Hospital of Philadelphia, allows researchers to test potential cancer targets directly in patient leukemia cells.

    2 min. read

    Cancer care for the mind and spirit
    Rebecca Boswell speaking with three people.

    Patients are 10 times more likely to engage in mental health services when the therapy is integrated in a medical clinic, says Rebecca Boswell, center, with therapists at the Psychosocial Oncology Clinic.

    (Image: Courtesy of Penn Medicine News)

    Cancer care for the mind and spirit

    A psychosocial oncology program is a part of a revolution in cancer care at Penn Medicine to address a wider range of cancer patients’ experiences, and includes specially-trained psychotherapists at no cost.

    From Penn Medicine News

    2 min. read