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Armoring CAR T cells to take on cancer
3D visualization showing a reddish-blue tumor mass with internal vasculature, surrounded by blue CAR T cells and small extracellular vesicles against a dark background.

Wei Guo of the School of Arts & Sciences and colleagues from the Perelman School of Medicine, School of Veterinary Medicine, and School of Engineering and Applied Science have teamed up to uncover how solid tumors’ complicated microenvironments can manipulate cancer-fighting CAR T cells through extracellular vesicles, causing the engineered CAR T cells to commit fratricide—essentially turning against each other instead of attacking the cancer.

(Image: iStock / Marcin Klapczynski)

Armoring CAR T cells to take on cancer

Wei Guo of the School of Arts & Sciences and colleagues from the Perelman School of Medicine, School of Veterinary Medicine, and School of Engineering and Applied Science have uncovered how solid tumors manipulate cancer-fighting CAR T cells through extracellular vesicles, causing the engineered CAR T cells to commit fratricide—essentially turning against each other instead of attacking the cancer.

3 min. read

Five Penn faculty elected to the American Academy of Arts and Sciences
Top row: Dennis Discher, Michael Correa-Jones, and Cherie Kagan. Bottom row: Sophie Rosenfeld and Susan Weiss.

Top row: Dennis Discher, Michael Correa-Jones, and Cherie Kagan. Bottom row: Sophie Rosenfeld and Susan Weiss.

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Five Penn faculty elected to the American Academy of Arts and Sciences

Dennis E. Discher, Michael Jones-Correa, Cherie R. Kagan, Sophia Rosenfeld, and Susan R. Weiss are being recognized for their contributions to engineering, political science, history, and biology.

3 min. read

Perry World House hosts expert roundtable on the margins of the 2025 World Bank and International Monetary Fund spring meetings

Perry World House hosts expert roundtable on the margins of the 2025 World Bank and International Monetary Fund spring meetings

Penn’s Perry World House, the International Peace Institute, and United Nations University hosted an expert roundtable discussion featuring policymakers, academics, and practitioners exploring the steps that multilateral institutions, countries, and subnational actors might take to meet the climate finance ambitions agreed in Baku.

An ‘archival discovery’ about a 17th-century Shakespeare Folio
a burned Shakespeare Folio in a glass box

A the remains of a burned Shakespeare Folio in a sealed glass case is part of the Penn Libraries collection. 

(Image: Courtesy of the Penn Libraries)

An ‘archival discovery’ about a 17th-century Shakespeare Folio

In the Penn Libraries is a sealed glass box containing the charred pages of a 17th-century Folio, a collection of plays by William Shakespeare. An archival discovery by Penn faculty proves that it is from the Third Folio, not the First as it was previously identified.

3 min. read

How Penn engineers are restoring historic Springfield Mills
Jason Pastor and another lab worker at Penn’s MEAM lab.

Jason Pastor (left) is a senior coordinator of instructional labs at the Department of Mechanical Engineering and Applied Mechanics (MEAM) at Penn Engineering.

(Image: Courtesy of Penn Engineering)

How Penn engineers are restoring historic Springfield Mills

The gristmill on Wissahickon Creek, which dates back to 1761, required repairs to its modern machinery upgrades. Volunteers at the Morris Arboretum & Gardens turned to MEAM’s Precision Manufacturing Lab at Penn Engineering for the design of precision components.

From Penn Engineering

2 min. read

Connecting with Philadelphia’s immigrant Asian communities through food
Rahim Ullah stands in front of a class of students speaking.

In conversation with Fariha Khan during the Asian American Food course, Rahim Ullah (standing) speaks about his food truck and experience immigrating to the United States. 

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Connecting with Philadelphia’s immigrant Asian communities through food

Through the Asian American Food course with Fariha Khan, students explore the many depths of the immigrant experience of different Asian ethnic groups to learn about history and culture.

6 min. read

The economic impact of tariffs

The economic impact of tariffs

Sweeping tariffs would raise new revenue, but they would also depress GDP, wages, and Treasury bond demand and prices, according to the nonpartisan Penn Wharton Budget Model.

News on climate change is more persuasive than expected

News on climate change is more persuasive than expected

In a new paper, Computational Social Science Lab postdoctoral researcher Amir Tohidi and colleagues find that exposure to articles about climate change significantly increases climate change concerns among skeptics.

From Annenberg School for Communication

2 min. read

Newash-Campbell breaks 93-year-old school record in 400m
Nayyir Newash-Campbell running the 400m.

Nayyir Newash-Campbell’s time of 46.14 is first in the Ivy League.

(Image: Penn Athletics)

Newash-Campbell breaks 93-year-old school record in 400m

The second-year sprinter topped Bill Carr’s mark, which was set in 1932.

From Penn Athletics

1 min. read