
When the Hippo pathway is “off,” the downstream protein YAP (red) is localized to the nucleus. VP40 (cyan), a viral matrix protein found in the Ebola virus, simultaneously drives vigorous formation and egress of virus-like particles along the cell periphery. In addition, Ebola virus nucleoprotein directs the formation of cytoplasmic inclusion bodies (yellow), also known as viral factories, in which viral RNA synthesis (transcription and replication) occurs.
(Image: Courtesy of Ronald Harty)