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CAR T cells suppress GI solid tumor cells without toxicity to healthy tissue
Microscopic view of T cells.

CDH17 CAR T cells attack a tumor but spare healthy tissue. (Image: Penn Medicine News)

CAR T cells suppress GI solid tumor cells without toxicity to healthy tissue

New research finds that CAR T cells can eliminate solid tumors, but do not damage healthy, normal tissues that also express a tumor antigen, because the tumor antigen is sequestered and hidden between the normal cells.

Caren Begun

Industrial robots and population health: A deadly mix
A robot typing on a laptop at a table.

Industrial robots and population health: A deadly mix

A new Penn study demonstrates how, over the last 40 years, high-tech factory automation has enhanced business operations at the same time it has generated widespread “deaths of despair” and other health problems in communities with ousted human workers.

Hoag Levins

Hands to hold on the path to surgery
A medical professional sits with a patient at their desk.

Hands to hold on the path to surgery

The first-of-its kind Center for Surgical Health provides navigation and support to help under- and uninsured patients receive surgical treatment before it becomes an emergency.

From Penn Medicine Service in Action

From a pandemic, scientific insights poised to impact more than just COVID-19
emulsions of oil and water separated by a layer of nanoparticles.

Bijels, or bicontinuous interfacially jammed emulsion gels, are structured emulsions of oil and water that are kept separated by a layer of nanoparticles. Penn Engineering researchers will develop a way of using them to manufacture mRNA-based therapeutics. (Image: Penn Engineering Today)

From a pandemic, scientific insights poised to impact more than just COVID-19

Pivoting to study SARS-CoV-2, many scientists on campus have launched new research projects that address the challenges of the pandemic but also prepare us to confront future challenges.

Katherine Unger Baillie

New COVID-19 roadmap: Four takeaways
A group of older people at a restaurant clinking half-full wine glasses, with their masks pulled down around their chins to reveal a smile. Food is on the table.

New COVID-19 roadmap: Four takeaways

A report spearheaded by PIK Professor Ezekiel Emanuel, with input from other Penn experts, lays out a dozen priorities for the federal government to tackle in the next 12 months. The aim: to help guide the U.S. to the pandemic’s “next normal.”

Michele W. Berger

The pandemic’s psychological scars
swirly painting of faces and heads

(Homepage image) “What we needed to do for our physical health—quarantining, staying away from other people and social situations—even when that kind of avoidance is the right thing to do, it makes people more anxious,” says Elizabeth Turk-Karan of the Center for the Study and Treatment of Anxiety. What remains to be seen is how these emotions and many others will play out as the pandemic recedes.

The pandemic’s psychological scars

It’s been a long and uncertain road, with some groups shouldering a disproportionately greater burden of mental anguish from COVID-19. Yet now there’s a glimmer of hope. Has the page finally turned?

Michele W. Berger

Feeling foggy? Your head is in the clouds for a reason
Person’s chest and torso but head is replaced by a small cloud.

Feeling foggy? Your head is in the clouds for a reason

It may be because you’re languishing—a feeling of stagnation or emptiness. And naming it is a first important step to bringing clarity to one’s experiences, says Wharton’s Adam Grant.

Sister physicians share passion for local and global health equity
Four medical personnel smiling at a desk in a clinic in the Philippines.

Trina (second from left) and Nicole (right) volunteering with two nurses at the JR Borja General Hospital in the Philippines in 2019. (Image: Penn Medicine News)

Sister physicians share passion for local and global health equity

Trina and Nicole Salva are both OB/GYNs in Philadelphia whose outreach extends to underserved communities in the city, and to the Philippines—their family’s birthplace.

From Penn Medicine News

A Ukrainian watches their country at war
Alice Sukhina in Ukraine holding a large Ukrainian flag wearing a flower crown.

Alice Sukhina casting their first-ever vote in an election in 2019 at the Ukrainian embassy in New York City.

A Ukrainian watches their country at war

Ph.D. student Alice Sukhina watched on their computer at Penn as their hometown of Zaporizhzhia, Ukraine, was invaded by Russian troops. While their parents were able to leave Ukraine, the rest of their family remains; Sukhina has been working nonstop to provide aid from afar.