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How sex differences may influence lung injury
Lung cells with RNA labeled in pink in each cell

AT2 cells, a type of lung cell that produces surfactant and give rise to gas-exchanging cells, can be infected by SARS-CoV-2. Research by Penn Vet scientists showed that differences in gene expression between male and female AT2 cells may help explain why older males have more severe outcomes from COVID-19 and similar diseases. (Image: Courtesy of the Anguera laboratory)

How sex differences may influence lung injury

Comparing lung cells from male and female mice, School of Veterinary Medicine scientists found gene expression differences that may explain why older males are at a higher risk than females for worse outcomes from COVID-19 and similar diseases.

Katherine Unger Baillie

What secrets might 2-million-year-old DNA hold?
Icy landscape in Greenland

Genetic material extracted from permafrost in northern Greenland revealed the presence of a rich, warm, and vibrant ancient ecosystem in what is today a cold and rather barren landscape, offering promise for future scientific discovery based on ancient environmental DNA.

What secrets might 2-million-year-old DNA hold?

Scientists from Denmark recently extracted and sequenced the oldest-ever DNA, from permafrost in Greenland, revealing a robust ecosystem of 135 species. Penn Today spoke with four faculty members about the potential power of ancient DNA.

Katherine Unger Baillie

A target for improving recovery from lung injury
Microscopic image of lung with cells labeled in blue, red, and green

A target for improving recovery from lung injury

After a bout of severe respiratory disease, some patients never fully recover. New research from the School of Veterinary Medicine identifies a factor responsible for inappropriate tissue regrowth after infection, pointing to a possible therapeutic target.

Katherine Unger Baillie

People and places at Penn: Research
laia mogas

People and places at Penn: Research

From Charles Addams Fine Arts Hall to the Schuylkill River, four researchers share their science and their spaces.

Kristina García

An evolving animal health emergency
Two chickens in a grassy yard

An outbreak of avian influenza is impacting birds both wild and domestic. Penn Vet researchers are helping track and better understand the disease, which has affected more than 52 million birds in the United States this year.

An evolving animal health emergency

More than 52 million birds in the U.S. have been affected by an outbreak of avian influenza. Researchers at the School of Veterinary Medicine are supporting Pennsylvania’s diagnostic work and launching new investigations to better understand the virus.

Katherine Unger Baillie

At COP27, Penn showcased its diverse climate expertise on the world stage
The American continent is seen on a revolving globe

Image: AP Photo/Peter Dejong

At COP27, Penn showcased its diverse climate expertise on the world stage

More than 30 representatives from the University traveled to Sharm El Sheikh, Egypt, for two weeks of negotiations at this year’s United Nations climate change conference.

Marilyn Perkins, Michele W. Berger, Michele W. Berger

Recreating the adrenal gland in a petri dish
A pink stained microscopic image shows the round structure of adrenal organoids growing together

The structure and function of adrenal gland ‘organoids’ grown in a petri dish at the School of Veterinary Medicine closely replicated that of the human adrenal gland, according to a new study. (Image: Courtesy of the Sasaki laboratory)

Recreating the adrenal gland in a petri dish

A School of Veterinary Medicine–led team coaxed stem cells to take on the characteristics and functions of a human adrenal gland, progress that could lead to new therapies for adrenal insufficiencies and a deeper understanding of the genetics of such disorders.

Katherine Unger Baillie

A FLASH of radiation may pave the way toward new cancer care for people and pets alike
Meg Ruller with her dog Maple in front of Penn Vet

(Homepage image) Meg Ruller, a 2018 graduate of the School of Veterinary Medicine, calls the FLASH trials “a fantastic opportunity” for Maple to receive a cutting-edge treatment—and to contribute to a scientific understanding of how FLASH radiation might help others in the future.

A FLASH of radiation may pave the way toward new cancer care for people and pets alike

Led by the Perelman School of Medicine’s Keith Cengel and the School of Veterinary Medicine’s Brian Flesner, a new study is evaluating the safety and efficacy of treating oral cancer in dogs with a palliative radiation in just two clinic visits.

Katherine Unger Baillie

Want a good read? Check out these award-winning stories
View of Fisher Fine Arts Library and College Green through a large window inside Van Pelt library seating area.

Want a good read? Check out these award-winning stories

From the opening of the Penn Medicine Pavilion to the intricacies of broadband expansion—read some recent Penn Today stories that won district awards from the Council for Advancement and Support of Education.

Dee Patel

NIH-funded canine immunotherapy data center charts a path toward transformative therapies
happy looking golden retriever in a clinic's kennel area

Researchers have learned much from treating dogs like Fantine, a golden retriever owned by Penn Vet supporter Richard Lichter, with immunotherapies for cancer, in part because tumors in dogs can closely resemble those in humans. With new support from the National Institutes of Health, a Penn-led team is ensuring such lessons can effectively translate into new therapeutic approaches. (Image: John Donges/Penn Vet)

NIH-funded canine immunotherapy data center charts a path toward transformative therapies

With support recently granted for five more years, Nicola Mason of the School of Veterinary Medicine and Qi Long of the Perelman School of Medicine hope their work leads to new insights in cancer care for people as well as pets.

Katherine Unger Baillie