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Bioengineering
A lipid nanoparticle delivers an mRNA cure for preeclampsia
A lipid nanoparticle delivers an mRNA cure for preeclampsia
Doctoral student Kelsey Swingle developed a lipid nanoparticle that delivers an mRNA therapeutic that reduces maternal blood pressure through the end of gestation and improves fetal health and blood circulation in the placenta.
Refining lipid nanoparticles for better mRNA therapies
Refining lipid nanoparticles for better mRNA therapies
A new method developed by Penn engineers for designing ionizable lipids is expected to have broad implications for mRNA-based vaccines and therapeutics.
Penn fourth-year Om Gandhi is a 2025 Rhodes Scholar
Penn fourth-year Om Gandhi is a 2025 Rhodes Scholar
Penn fourth-year Om Gandhi, from Barrington, Illinois, has been awarded a 2025 Rhodes Scholarship, which funds tuition and a living stipend for graduate study at the University of Oxford in England. He is among 32 American Rhodes Scholars, and an expected 100 worldwide.
Developing kidneys from scratch
Developing kidneys from scratch
Bioengineering professor Alex Hughes tackles the burden of chronic kidney disease by creating kidney tissue from scratch, which could reduce the need for both dialysis and transplantation.
New class of encrypted peptides offer hope in fight against antibiotic resistance
New class of encrypted peptides offer hope in fight against antibiotic resistance
New research by César de la Fuente finds that nearly 90% of peptides discovered exhibit significant antimicrobial properties, particularly through the disruption of bacterial membranes.
Siloxane-enhanced nanoparticles chart a new path in precision mRNA medicine
Siloxane-enhanced nanoparticles chart a new path in precision mRNA medicine
By adjusting the chemical structure of lipid nanoparticles Penn Engineers have discovered how to target specific organs, a major breakthrough in precision medicine.
Penn’s Gilliam Fellows bridge inclusion and innovation
Penn’s Gilliam Fellows bridge inclusion and innovation
Two Ph.D. students are among 50 graduate students selected to receive this year’s Howard Hughes Medical Institute Gilliam Fellowship, which advances equity and inclusion in science through a mentorship skills development course.
Liquid crystals in motion mimic biological systems
Liquid crystals in motion mimic biological systems
Researchers in the lab of Chinedum Osuji have discovered that under the right conditions, liquid crystals form structures reminiscent of biological systems that can transport material from one place to another, much like complex biological systems.
Uncovering new antibiotics inside the human gut
Uncovering new antibiotics inside the human gut
Researchers from Penn Engineering, led by César de la Fuente, have leveraged AI to discover dozens of potential new antibiotics in the human gut microbiome.
Building solutions for brain disorders
Building solutions for brain disorders
Penn Engineering’s Flavia Vitale’s work developing devices that help people living with brain disorders has earned her a CAREER award, which will support her lab’s research in materials and devices that interface with different chemical and electrical signals inside the brain.
In the News
HealthDay
In mouse studies, new hope against a dangerous complication of pregnancy
Doctoral student Kelsey Swingle in the School of Engineering and Applied Science and colleagues are using mRNA molecules to treat pre-eclampsia, a common pregnancy complication.
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New Scientist
Pre-eclampsia could be treated with mRNA technology
Michael Mitchell and Ph.D. student Kelsey Swingle of the School of Engineering and Applied Science and colleagues are using mRNA molecules to treat pre-eclampsia, a common pregnancy complication.
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Axios
Real vs. fake Christmas trees: The great debate, explained
Lorena Grundy of the School of Engineering and Applied Science says that the debate between real and fake Christmas trees isn’t as black and white as it’s being portrayed.
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Rolling Stone
RFK Jr.’s 10 wildest medical theories
Kenneth R. Foster of the School of Engineering and Applied Science says studies haven’t provided clear evidence that exposure to levels of radio frequency energy below accepted limits, such as Wi-Fi, disrupts the blood-brain barrier.
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Nature
Gut microbes’ genomes are a trove of potential antibiotics
Marcelo Torres of the School of Engineering and Applied Science and colleagues are synthesizing antibiotic microbes from microbiomes in the human gut.
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Pittsburgh Post-Gazette
Smart meter debate: Small group of consumers pushes against a meter mandate in Pennsylvania
Kenneth Foster of the School of Engineering and Applied Science says that the most reliable conclusions are always those of expert panels that conduct systematic reviews according to established procedures.
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