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Bioengineering

A suit of armor for cancer-fighting cells
3d render of T cells attacking cancer cells

Chimeric antigen receptor T cell (CAR T) therapy has delivered promising results, transforming the fight against various forms of cancer, but for many, the therapy comes with severe and potentially lethal side effects. Now, a research team led by Michael Mitchell of the School of Engineering and Applied Science has found a solution that could help CAR T therapies reach their full potential while minimizing severe side effects.

(Image: iStock / Meletios Verras)

A suit of armor for cancer-fighting cells

New research from the University of Pennsylvania offers a safer path for CAR T cell immunotherapy.
A low-cost, eco-friendly COVID test
cesar de la fuente in his lab

A low-cost, eco-friendly COVID test

César de la Fuente and a team of Penn engineers work on creative ways to create faster and cheaper testing for COVID-19. Their latest innovation incorporates speed and cost-effectiveness with eco-friendly materials.

From Penn Engineering Today

The physics of fat droplets reveal DNA danger
Microscopic view of fat molecules.

Image: Courtesy of Penn Medicine News

The physics of fat droplets reveal DNA danger

Penn Engineers are the first to discover fat-filled lipid droplets’ surprising capability to indent and puncture the nucleus, the organelle which contains and regulates a cell’s DNA.

Devorah Fischler

SCALAR: A microchip designed to transform the production of mRNA therapeutics and vaccines
Silicon wafer with chips lightinhg in neon light.

Led by Michael Mitchell and David Issadore of the School of Engineering and Applied Science, a team of researchers has developed a platform that could rapidly accelerate the development of mRNA-based lipid nanoparticle vaccines and therapeutics at both the small and large scale, SCALAR.

(Image: iStock / Anatoly Morozov)

SCALAR: A microchip designed to transform the production of mRNA therapeutics and vaccines

Researchers have developed a platform that could rapidly accelerate the development of mRNA-based lipid nanoparticle vaccines and therapeutics at both the small and largescale, SCALAR.
QR code for cancer cells
Microscopic view of a DNA chain disintegrating.

Image: iStock/ktsimage

QR code for cancer cells

Researchers from Penn Engineering have created a new synthetic biology approach to uncover why some cells become resistant to anti-cancer therapies.

From Penn Engineering Today