Understanding the cellular mechanisms driving solid tumors’ robust defense system In a collaborative interdisciplinary study, Michael Mitchell of the School of Engineering and Applied Science, Wei Guo of the School of Arts & Sciences, and Drew Weissman of the Perelman School of Medicine show that solid tumors can block drug-delivery mechanisms with a “forcefield-like” effect but certain genetic elements that can effectively “shut down” the forcefield. Their findings hint at new targets for delivering cancer treatments that use the body’s immune system to fight tumors.(Image: iStock / CIPhotos) Understanding the cellular mechanisms driving solid tumors’ robust defense system Researchers from Penn have identified a “forcefield-like” defense system in solid tumors and the genetic elements that can switch it off.
A modified peptide shows promise for fighting tumors A collaborative team of researchers including scientists from the School of Veterinary Medicine and Perelman School of Medicine show how a modified peptide can successfully target the immunosuppressive tumor microenvironment.(Image: iStock/Marcin Klapczynski) A modified peptide shows promise for fighting tumors Researchers in Penn Vet led a collaborative study that demonstrates how a modified peptide normalizes tumor vasculature and enhances various cancer treatments.
Improving care for patients with acute lymphocytic leukemia Image: Courtesy of Penn Medicine News Improving care for patients with acute lymphocytic leukemia How one Penn Medicine patient’s role in a clinical trial for acute lymphocytic leukemia therapy brought a cancer-free diagnosis and FDA approval.
Carl June: 2024 will be seen as a breakthrough year for brain cancer Penn In the News Forbes Carl June: 2024 will be seen as a breakthrough year for brain cancer Carl June of the Perelman School of Medicine shares five insights on using CAR T cell therapy to combat cancer, featuring remarks from Bruce Levine. Penn plans to build a proton center for cancer treatment at Presbyterian Medical Center Penn In the News Philadelphia Inquirer Penn plans to build a proton center for cancer treatment at Presbyterian Medical Center Penn Medicine will build its fourth proton beam center for cancer treatment at Penn Presbyterian Medical Center in University City. A newly identified immune checkpoint protein may lead to future cancer therapies Image: iStock/cgtoolbox A newly identified immune checkpoint protein may lead to future cancer therapies Penn Medicine researchers have found that knocking out a T cell’s CD5 gene greatly enhances the cell’s anticancer activity in a variety of preclinical cancer models. Double mastectomies do not improve breast cancer survival likelihood for most women, study finds Penn In the News PhillyVoice Double mastectomies do not improve breast cancer survival likelihood for most women, study finds Angela DeMichele of the Perelman School of Medicine says that chemotherapy and hormonal therapies are important for combating breast cancer because they’re designed to kill spreading cells. Breast cancer survival not boosted by double mastectomy, study says Penn In the News The New York Times Breast cancer survival not boosted by double mastectomy, study says Angela DeMichele of the Perelman School of Medicine comments on a study which found that breast cancer survival is not boosted by a double mastectomy. How did Shannen Doherty die? What to know about ‘90210’ star’s cause of death Penn In the News Today How did Shannen Doherty die? What to know about ‘90210’ star’s cause of death According to Penn Medicine, there is no known cure for metastatic breast cancer. Penn pioneers a ‘one-pot platform’ to promptly produce mRNA delivery particles Lipid nanoparticles present one of the most advanced drug delivery platforms to shuttle promising therapeutics such as mRNA but are limited by the time it takes to synthesize cationic lipids, a key component. Now, Michael Mitchell and his team at the School of Engineering and Applied Science have developed a faster way to make cationic lipids that are also more versatile, able to carry different kinds of treatments to target specific organs.(Image: iStock / Dr_Microbe) Penn pioneers a ‘one-pot platform’ to promptly produce mRNA delivery particles New lipid platform enables rapid synthesis of molecules that can shuttle therapeutics for a range of diseases with a high degree of organ specificity. Load More
Penn plans to build a proton center for cancer treatment at Presbyterian Medical Center Penn In the News Philadelphia Inquirer Penn plans to build a proton center for cancer treatment at Presbyterian Medical Center Penn Medicine will build its fourth proton beam center for cancer treatment at Penn Presbyterian Medical Center in University City. A newly identified immune checkpoint protein may lead to future cancer therapies Image: iStock/cgtoolbox A newly identified immune checkpoint protein may lead to future cancer therapies Penn Medicine researchers have found that knocking out a T cell’s CD5 gene greatly enhances the cell’s anticancer activity in a variety of preclinical cancer models. Double mastectomies do not improve breast cancer survival likelihood for most women, study finds Penn In the News PhillyVoice Double mastectomies do not improve breast cancer survival likelihood for most women, study finds Angela DeMichele of the Perelman School of Medicine says that chemotherapy and hormonal therapies are important for combating breast cancer because they’re designed to kill spreading cells. Breast cancer survival not boosted by double mastectomy, study says Penn In the News The New York Times Breast cancer survival not boosted by double mastectomy, study says Angela DeMichele of the Perelman School of Medicine comments on a study which found that breast cancer survival is not boosted by a double mastectomy. How did Shannen Doherty die? What to know about ‘90210’ star’s cause of death Penn In the News Today How did Shannen Doherty die? What to know about ‘90210’ star’s cause of death According to Penn Medicine, there is no known cure for metastatic breast cancer. Penn pioneers a ‘one-pot platform’ to promptly produce mRNA delivery particles Lipid nanoparticles present one of the most advanced drug delivery platforms to shuttle promising therapeutics such as mRNA but are limited by the time it takes to synthesize cationic lipids, a key component. Now, Michael Mitchell and his team at the School of Engineering and Applied Science have developed a faster way to make cationic lipids that are also more versatile, able to carry different kinds of treatments to target specific organs.(Image: iStock / Dr_Microbe) Penn pioneers a ‘one-pot platform’ to promptly produce mRNA delivery particles New lipid platform enables rapid synthesis of molecules that can shuttle therapeutics for a range of diseases with a high degree of organ specificity. Load More
A newly identified immune checkpoint protein may lead to future cancer therapies Image: iStock/cgtoolbox A newly identified immune checkpoint protein may lead to future cancer therapies Penn Medicine researchers have found that knocking out a T cell’s CD5 gene greatly enhances the cell’s anticancer activity in a variety of preclinical cancer models.
Double mastectomies do not improve breast cancer survival likelihood for most women, study finds Penn In the News PhillyVoice Double mastectomies do not improve breast cancer survival likelihood for most women, study finds Angela DeMichele of the Perelman School of Medicine says that chemotherapy and hormonal therapies are important for combating breast cancer because they’re designed to kill spreading cells. Breast cancer survival not boosted by double mastectomy, study says Penn In the News The New York Times Breast cancer survival not boosted by double mastectomy, study says Angela DeMichele of the Perelman School of Medicine comments on a study which found that breast cancer survival is not boosted by a double mastectomy. How did Shannen Doherty die? What to know about ‘90210’ star’s cause of death Penn In the News Today How did Shannen Doherty die? What to know about ‘90210’ star’s cause of death According to Penn Medicine, there is no known cure for metastatic breast cancer. Penn pioneers a ‘one-pot platform’ to promptly produce mRNA delivery particles Lipid nanoparticles present one of the most advanced drug delivery platforms to shuttle promising therapeutics such as mRNA but are limited by the time it takes to synthesize cationic lipids, a key component. Now, Michael Mitchell and his team at the School of Engineering and Applied Science have developed a faster way to make cationic lipids that are also more versatile, able to carry different kinds of treatments to target specific organs.(Image: iStock / Dr_Microbe) Penn pioneers a ‘one-pot platform’ to promptly produce mRNA delivery particles New lipid platform enables rapid synthesis of molecules that can shuttle therapeutics for a range of diseases with a high degree of organ specificity. Load More
Breast cancer survival not boosted by double mastectomy, study says Penn In the News The New York Times Breast cancer survival not boosted by double mastectomy, study says Angela DeMichele of the Perelman School of Medicine comments on a study which found that breast cancer survival is not boosted by a double mastectomy. How did Shannen Doherty die? What to know about ‘90210’ star’s cause of death Penn In the News Today How did Shannen Doherty die? What to know about ‘90210’ star’s cause of death According to Penn Medicine, there is no known cure for metastatic breast cancer. Penn pioneers a ‘one-pot platform’ to promptly produce mRNA delivery particles Lipid nanoparticles present one of the most advanced drug delivery platforms to shuttle promising therapeutics such as mRNA but are limited by the time it takes to synthesize cationic lipids, a key component. Now, Michael Mitchell and his team at the School of Engineering and Applied Science have developed a faster way to make cationic lipids that are also more versatile, able to carry different kinds of treatments to target specific organs.(Image: iStock / Dr_Microbe) Penn pioneers a ‘one-pot platform’ to promptly produce mRNA delivery particles New lipid platform enables rapid synthesis of molecules that can shuttle therapeutics for a range of diseases with a high degree of organ specificity. Load More
How did Shannen Doherty die? What to know about ‘90210’ star’s cause of death Penn In the News Today How did Shannen Doherty die? What to know about ‘90210’ star’s cause of death According to Penn Medicine, there is no known cure for metastatic breast cancer. Penn pioneers a ‘one-pot platform’ to promptly produce mRNA delivery particles Lipid nanoparticles present one of the most advanced drug delivery platforms to shuttle promising therapeutics such as mRNA but are limited by the time it takes to synthesize cationic lipids, a key component. Now, Michael Mitchell and his team at the School of Engineering and Applied Science have developed a faster way to make cationic lipids that are also more versatile, able to carry different kinds of treatments to target specific organs.(Image: iStock / Dr_Microbe) Penn pioneers a ‘one-pot platform’ to promptly produce mRNA delivery particles New lipid platform enables rapid synthesis of molecules that can shuttle therapeutics for a range of diseases with a high degree of organ specificity.
Penn pioneers a ‘one-pot platform’ to promptly produce mRNA delivery particles Lipid nanoparticles present one of the most advanced drug delivery platforms to shuttle promising therapeutics such as mRNA but are limited by the time it takes to synthesize cationic lipids, a key component. Now, Michael Mitchell and his team at the School of Engineering and Applied Science have developed a faster way to make cationic lipids that are also more versatile, able to carry different kinds of treatments to target specific organs.(Image: iStock / Dr_Microbe) Penn pioneers a ‘one-pot platform’ to promptly produce mRNA delivery particles New lipid platform enables rapid synthesis of molecules that can shuttle therapeutics for a range of diseases with a high degree of organ specificity.