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Understanding the cellular mechanisms driving solid tumors’ robust defense system
A 3D rendering of the tumor microenvironment with cancer cells, T-Cells, nanoparticles, cancer associated fibroblast layer of tumor microenvironment normal cells, molecules, and blood vessels.

In a collaborative interdisciplinary study, Michael Mitchell of the School of Engineering and Applied Science, Wei Guo of the School of Arts & Sciences, and Drew Weissman of the Perelman School of Medicine show that solid tumors can block drug-delivery mechanisms with a “forcefield-like” effect but certain genetic elements that can effectively “shut down” the forcefield. Their findings hint at new targets for delivering cancer treatments that use the body’s immune system to fight tumors.

(Image: iStock / CIPhotos)

Understanding the cellular mechanisms driving solid tumors’ robust defense system

Researchers from Penn have identified a “forcefield-like” defense system in solid tumors and the genetic elements that can switch it off.
NASA’s Roman Space Telescope will investigate the history of galaxies
artist's concept of the Andromeda galaxy's stellar halo, depicted with exaggerated brightness and density, highlighting the extent of this faint and loosely connected collection of stars that surrounds the galaxy.

Robyn Sanderson and Adrien Thob of the School of Arts & Sciences are part of a team of astronomers using NASA’s upcoming Nancy Grace Roman Space Telescope to uncover the “fossil record” of the universe as they look to clues to unearth key insights into its formation.

(Image: Courtesy of NASA, Ralf Crawford (STScI))

NASA’s Roman Space Telescope will investigate the history of galaxies

Robyn Sanderson and collaborators are unearthing the history of the universe’s formation by looking for clues that reveal its “galactic fossil record.”
Telling the story of a Hispanic war hero
President Reagan presenting Roy Benavidez with the Medal of Honor in 1981.

President Reagan presenting retired Army Master Sergeant Roy Benavidez with the Medal of Honor in 1981.

(Image: The U.S. National Archives)

Telling the story of a Hispanic war hero

In his new book “The Ballad of Roy Benavidez,” Penn historian William Sturkey explores the life of this Hispanic war hero, his fight to maintain veteran disability benefits, and the ways in which Hispanic Americans have long shaped U.S. history with scant acknowledgement.

From Omnia

Mark Wolff reappointed dean of the Penn School of Dental Medicine
Mark Wolff.

nocred

Mark Wolff reappointed dean of the Penn School of Dental Medicine

Wolff’s reappointment follows a comprehensive review of the major accomplishments of his first term as dean, including new mission and vision statement for the School, new programs and interdisciplinary centers, and advancing an inclusive learning environment.
Uncovering new antibiotics inside the human gut
Microscopic rendering of bacterial in the small intestines.

Image: iStock/ChrisChrisW

Uncovering new antibiotics inside the human gut

Researchers from Penn Engineering, led by César de la Fuente, have leveraged AI to discover dozens of potential new antibiotics in the human gut microbiome.

Ian Scheffler

A mission to supercharge scientific research
A doctor using AI and machine learning on a computer.

Image: iStock/ipopba

A mission to supercharge scientific research

Jacob Gardner, an assistant professor in computer and information science, wants to leverage AI to accelerate scientific research across disciplines.

Ian Scheffler

Pushing the limits of scientific discovery with machine learning
Computer code.

Image: iStock/iambuff

Pushing the limits of scientific discovery with machine learning

Penn Engineering’s Nat Trask is combining applied mathematics and traditional physics modeling with the powers of machine learning to design some of his first machine-learning-powered, self-driving labs at Penn.

Melissa Pappas