Penn-made AI tool matched a patient’s rare disease with a common inflammation drug. He’s been in remission for over two years Penn In the News Philadelphia Inquirer Penn-made AI tool matched a patient’s rare disease with a common inflammation drug. He’s been in remission for over two years Every Cure, a nonprofit founded by David Fajgenbaum of the Perelman School of Medicine, has received $108 million in federal contracts and private financing to identify promising disease-medication matches and make recommendations for further clinical study. Researchers create genetic map tied to kidney disease Image: iStock/TanyaJoy Researchers create genetic map tied to kidney disease The creation of the most complete map of more than 1,000 genes that influence kidney function could help experts diagnose and design targeted treatments for kidney disease. Breakthroughs in gene editing and expression control with mvGPT Sherry Gao, Tyler Daniel (pictured), and their coauthors have developed a new tool that can simultaneously and independently edit multiple genes and regulate their expression.(Image: Bella Ciervo) Breakthroughs in gene editing and expression control with mvGPT Penn Engineers have created a gene editing tool that can address different genetic diseases in the same cell. What’s That? Black squirrels A black squirrel on College Green in the fall of 2024. nocred What’s That? Black squirrels Penn Today spoke to Sarah Tomke in the School of Veterinary Medicine’s Wildlife Futures Program about the black squirrels regularly seen on College Green. They are black because of a genetic mutation in the melanin receptor protein, which regulates pigment. New tool puts reproductive risk for BRCA carriers into perspective Image: iStock/baona New tool puts reproductive risk for BRCA carriers into perspective A team at Penn Medicine has created a resource to help inform reproductive counseling for cancer gene mutation carriers. Cancer breakthrough as ‘speckles’ may reveal best treatment Penn In the News Newsweek Cancer breakthrough as ‘speckles’ may reveal best treatment A paper co-authored by PIK Professor Shelley Berger finds that patterns of “speckles” in the heart of tumor cells could help predict how patients with a common form of kidney cancer will respond to treatment options. For kids with rare genetic disorders, customized CRISPR treatments offer hope Penn In the News NPR For kids with rare genetic disorders, customized CRISPR treatments offer hope Scientists at Penn are trying to develop a template for groups of rare conditions that are similar enough to be affected by a single, easily adaptable gene-editing treatment. A Philly biotech got $60M from a TED initiative for AI in medicine Penn In the News Philadelphia Inquirer A Philly biotech got $60M from a TED initiative for AI in medicine David Fajgenbaum of the Perelman School of Medicine helped found Every Cure, a biotechnology nonprofit that employs AI to help match existing treatments to new diseases. An integral T cell pathway helps regulate female gene expression Image: iStock/Alllex An integral T cell pathway helps regulate female gene expression Penn Vet researchers have revealed a connection between NF-κB signaling pathways and X chromosome inactivation, which has implications for understanding sex-based immune responses during infection. Understanding diabetes and oral health From left: Su Ah Kim, professor of periodontics Dana Graves, and Sanan Gueyikian.nocred Understanding diabetes and oral health Two undergraduates, supported by PURM, worked on research projects this summer with the Graves Lab to contribute to the knowledge of diabetes’ impact on oral wound healing and periodontal disease. Load More
Researchers create genetic map tied to kidney disease Image: iStock/TanyaJoy Researchers create genetic map tied to kidney disease The creation of the most complete map of more than 1,000 genes that influence kidney function could help experts diagnose and design targeted treatments for kidney disease.
Breakthroughs in gene editing and expression control with mvGPT Sherry Gao, Tyler Daniel (pictured), and their coauthors have developed a new tool that can simultaneously and independently edit multiple genes and regulate their expression.(Image: Bella Ciervo) Breakthroughs in gene editing and expression control with mvGPT Penn Engineers have created a gene editing tool that can address different genetic diseases in the same cell.
What’s That? Black squirrels A black squirrel on College Green in the fall of 2024. nocred What’s That? Black squirrels Penn Today spoke to Sarah Tomke in the School of Veterinary Medicine’s Wildlife Futures Program about the black squirrels regularly seen on College Green. They are black because of a genetic mutation in the melanin receptor protein, which regulates pigment.
New tool puts reproductive risk for BRCA carriers into perspective Image: iStock/baona New tool puts reproductive risk for BRCA carriers into perspective A team at Penn Medicine has created a resource to help inform reproductive counseling for cancer gene mutation carriers.
Cancer breakthrough as ‘speckles’ may reveal best treatment Penn In the News Newsweek Cancer breakthrough as ‘speckles’ may reveal best treatment A paper co-authored by PIK Professor Shelley Berger finds that patterns of “speckles” in the heart of tumor cells could help predict how patients with a common form of kidney cancer will respond to treatment options. For kids with rare genetic disorders, customized CRISPR treatments offer hope Penn In the News NPR For kids with rare genetic disorders, customized CRISPR treatments offer hope Scientists at Penn are trying to develop a template for groups of rare conditions that are similar enough to be affected by a single, easily adaptable gene-editing treatment. A Philly biotech got $60M from a TED initiative for AI in medicine Penn In the News Philadelphia Inquirer A Philly biotech got $60M from a TED initiative for AI in medicine David Fajgenbaum of the Perelman School of Medicine helped found Every Cure, a biotechnology nonprofit that employs AI to help match existing treatments to new diseases. An integral T cell pathway helps regulate female gene expression Image: iStock/Alllex An integral T cell pathway helps regulate female gene expression Penn Vet researchers have revealed a connection between NF-κB signaling pathways and X chromosome inactivation, which has implications for understanding sex-based immune responses during infection. Understanding diabetes and oral health From left: Su Ah Kim, professor of periodontics Dana Graves, and Sanan Gueyikian.nocred Understanding diabetes and oral health Two undergraduates, supported by PURM, worked on research projects this summer with the Graves Lab to contribute to the knowledge of diabetes’ impact on oral wound healing and periodontal disease. Load More
For kids with rare genetic disorders, customized CRISPR treatments offer hope Penn In the News NPR For kids with rare genetic disorders, customized CRISPR treatments offer hope Scientists at Penn are trying to develop a template for groups of rare conditions that are similar enough to be affected by a single, easily adaptable gene-editing treatment. A Philly biotech got $60M from a TED initiative for AI in medicine Penn In the News Philadelphia Inquirer A Philly biotech got $60M from a TED initiative for AI in medicine David Fajgenbaum of the Perelman School of Medicine helped found Every Cure, a biotechnology nonprofit that employs AI to help match existing treatments to new diseases. An integral T cell pathway helps regulate female gene expression Image: iStock/Alllex An integral T cell pathway helps regulate female gene expression Penn Vet researchers have revealed a connection between NF-κB signaling pathways and X chromosome inactivation, which has implications for understanding sex-based immune responses during infection. Understanding diabetes and oral health From left: Su Ah Kim, professor of periodontics Dana Graves, and Sanan Gueyikian.nocred Understanding diabetes and oral health Two undergraduates, supported by PURM, worked on research projects this summer with the Graves Lab to contribute to the knowledge of diabetes’ impact on oral wound healing and periodontal disease. Load More
A Philly biotech got $60M from a TED initiative for AI in medicine Penn In the News Philadelphia Inquirer A Philly biotech got $60M from a TED initiative for AI in medicine David Fajgenbaum of the Perelman School of Medicine helped found Every Cure, a biotechnology nonprofit that employs AI to help match existing treatments to new diseases. An integral T cell pathway helps regulate female gene expression Image: iStock/Alllex An integral T cell pathway helps regulate female gene expression Penn Vet researchers have revealed a connection between NF-κB signaling pathways and X chromosome inactivation, which has implications for understanding sex-based immune responses during infection. Understanding diabetes and oral health From left: Su Ah Kim, professor of periodontics Dana Graves, and Sanan Gueyikian.nocred Understanding diabetes and oral health Two undergraduates, supported by PURM, worked on research projects this summer with the Graves Lab to contribute to the knowledge of diabetes’ impact on oral wound healing and periodontal disease.
An integral T cell pathway helps regulate female gene expression Image: iStock/Alllex An integral T cell pathway helps regulate female gene expression Penn Vet researchers have revealed a connection between NF-κB signaling pathways and X chromosome inactivation, which has implications for understanding sex-based immune responses during infection.
Understanding diabetes and oral health From left: Su Ah Kim, professor of periodontics Dana Graves, and Sanan Gueyikian.nocred Understanding diabetes and oral health Two undergraduates, supported by PURM, worked on research projects this summer with the Graves Lab to contribute to the knowledge of diabetes’ impact on oral wound healing and periodontal disease.