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Monkeypox: What is known and unknown
People lined up near a sign that says NJCRI Monkeypox Vaccine Clinic

At a monkeypox vaccine clinic in Newark, New Jersey, in mid-August, people line up to receive a dose of the Jynneos vaccine. Monkeypox case counts have jumped significantly since the beginning of summer. (Image: AP Photo/Seth Wenig)

Monkeypox: What is known and unknown

The current outbreak of monkeypox is showing no sign of slowing. Stuart Isaacs of the Perelman School of Medicine, an expert on poxviruses, sheds light on the disease, its prevention and treatment, and what to watch for this fall.

Katherine Unger Baillie

Cancer cells selectively load ‘drones’ to keep T cells from infiltrating tumors
four panels show a cancerous tumor with some portions labeled in red, green, and blue, and a close up image of part of it

The researchers found that levels of phosphorylated HRS varied across tumors, negatively corresponding with the level of T cell infiltration in those areas. (Image: Guo lab/Nature Communications)

Cancer cells selectively load ‘drones’ to keep T cells from infiltrating tumors

Biologist Wei Guo and colleagues elucidate the process of sorting and loading cargo for these biological drones with implications for a more targeted and effective use of checkpoint inhibitor drugs in cancer treatment.

Katherine Unger Baillie

Deconstructing the mechanics of bone marrow disease
microscopic image of an immune cell labeled purple against a gray background

Acollaborative team developed an alginate-based hydrogel system that mimics the viscoelasticity of the natural extracellular matrix in bone marrow. By tweaking the balance between elastic and viscous properties in these artificial ECMs, they could recapitulate the viscoelasticity of healthy and scarred fibrotic bone marrow, and study the effects on human monocytes placed into these artificial ECMs. (Image: Adam Graham/Harvard CNS/Wyss Institute at Harvard University)

Deconstructing the mechanics of bone marrow disease

A new understanding of how mechanical features of bone marrow affect resident immune cells in a fibrotic cancer points to future therapeutic strategies for cancers and fibrotic diseases.

Katherine Unger Baillie

Regulating the regulators of the immune system
T cells labeled in fluorescent green patrol the vascular system, labeled in red

Regulating the regulators of the immune system

Research led by School of Veterinary Medicine scientists reveals a new layer of complexity with which the immune system finds a balance between controlling pathogens and protecting healthy tissue.

Katherine Unger Baillie

A decade of CAR T cell therapy 
Chemistry World

A decade of CAR T cell therapy 

In a feature on the history and future of CAR T, the work of Carl June, Michael C. Milone, Aimee Payne, Drew Weissman, and Jonathan Epstein from the Perelman School of Medicine is highlighted.

CAR T cells suppress GI solid tumor cells without toxicity to healthy tissue
Microscopic view of T cells.

CDH17 CAR T cells attack a tumor but spare healthy tissue. (Image: Penn Medicine News)

CAR T cells suppress GI solid tumor cells without toxicity to healthy tissue

New research finds that CAR T cells can eliminate solid tumors, but do not damage healthy, normal tissues that also express a tumor antigen, because the tumor antigen is sequestered and hidden between the normal cells.

Caren Begun

Decade-long remission after CAR T cell therapy
Two people stand closely together, smiling

Bill Ludwig, left, was the first patient to receive CAR T cells as part of clinical trials at Abramson Cancer Center. Carl June, right, has played a pioneering roll in the therapeutic use of CAR T cells. (Image: Penn Medicine)

Decade-long remission after CAR T cell therapy

Two patients represent longest-known CAR T cell response to date, providing insight into treatment effect and outcomes.

Caren Begun