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A suit of armor for cancer-fighting cells
3d render of T cells attacking cancer cells

Chimeric antigen receptor T cell (CAR T) therapy has delivered promising results, transforming the fight against various forms of cancer, but for many, the therapy comes with severe and potentially lethal side effects. Now, a research team led by Michael Mitchell of the School of Engineering and Applied Science has found a solution that could help CAR T therapies reach their full potential while minimizing severe side effects.

(Image: iStock / Meletios Verras)

A suit of armor for cancer-fighting cells

New research from the University of Pennsylvania offers a safer path for CAR T cell immunotherapy.
An immunotherapy strategy against all blood cancers
Microscopic rendering of a white blood cell amongst red blood cells.

Image: iStock/PhonlamaiPhoto

An immunotherapy strategy against all blood cancers

Researchers at Penn Medicine have demonstrated a new potential treatment using CAR T cell therapy using a CRISPR base-editing to develop a method called “epitope editing.”

From Penn Medicine News

Carl June on the boundless potential of CAR T cell therapy
Carl June with a microphone in the Penn Medicine atrium with the celebratory flash mob.

Carl June, at the flash mob celebration of the FDA approval of the CAR T cell therapy he developed, in August 2017.

(Image: Courtesy of Penn Medicine Magazine)

Carl June on the boundless potential of CAR T cell therapy

In a Q & A, June, the Richard W. Vague Professor in Immunotherapy, and Daniel Baker, a fourth-year doctoral student in Penn’s Cell and Molecular Biology department, discuss how the treatment can extend to treating diseases beyond cancer.

From Penn Medicine News

See how stress affects inflammatory bowel disease
Scientific American

See how stress affects inflammatory bowel disease

A study by Christoph A. Thaiss of the Perelman School of Medicine and colleagues has traced two detailed molecular pathways from the brain to the gut that produce inflammatory bowel disease flare-ups.

Putting biomedical research advances within reach
A medical worker gives a person a Covid vaccine.

Image: Courtesy of Penn Medicine Magazine

Putting biomedical research advances within reach

Treatments and vaccines are only useful in the hands of the people who need them, and Penn Medicine is working toward better access and equity for biomedical innovations.

Karen L. Brooks for Penn Medicine Magazine

A vaccine for pancreatic cancer?
Deutsche Welle

A vaccine for pancreatic cancer?

Drew Weissman of the Perelman School of Medicine comments on the efficacy of a potential pancreatic cancer vaccine.