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Novel coupled nanopore platform offers greater precision for detecting molecules
Artist depiction of DNA moving through a nanopore system.

Marija Drndić of the School of Arts & Sciences and Dimitri Monos of the Perelman School of Medicine and Children’s Hospital of Philadelphia led a team of researchers who developed a new nanostructure platform that allows for more precise detection and control of biomolecules, such as DNA and proteins. This exciting new platform signals a new era of synthetic biology, paving the way for enhanced DNA sequencing and protein conformation detection.

(Image: Courtesy of artist) 

Novel coupled nanopore platform offers greater precision for detecting molecules

An interdisciplinary team of researchers from Penn have created the first ever reusable coupled nanopore platform for detecting and guiding molecules, findings could pave the way for much improved DNA sequencing and molecule identification.
Understanding diabetes and oral health
Two students in lab coats surround a professor in a suit.

From left: Su Ah Kim, professor of periodontics Dana Graves, and Sanan Gueyikian.

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Understanding diabetes and oral health

Two undergraduates, supported by PURM, worked on research projects this summer with the Graves Lab to contribute to the knowledge of diabetes’ impact on oral wound healing and periodontal disease.
New biomarkers can help target treatment for chronic skin disease
Microscopic view of granulomatous tissue.

Cellular view of granulomatous tissue.

(Image: iStock/Md Saiful Islam Khan)

New biomarkers can help target treatment for chronic skin disease

Researchers at Penn Medicine have found a pathway in certain lymphoid cells that, once targeted, inhibit granulomas from forming in patients with sarcoidosis.

Alex Gardner

Testing a novel, community-driven response to heat islands in Philadelphia
Hanzhong Luo has his body heat scanned in a cooling shelter prototype.

Dorit Aviv uses an infrared camera to demonstrate the effects of the Tenopy’s radiant cooling panels on Hanzhong Luo.

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Testing a novel, community-driven response to heat islands in Philadelphia

Researchers from three University of Pennsylvania schools collaborated with a Hunting Park nonprofit to design, build, and test a prototype of a cooling shelter to place at a bus stop.
Gene therapy trial sees massive improvement in vision
Closeup view of an eyeball with a vision test graphic.

Image: iStock/murat4art

Gene therapy trial sees massive improvement in vision

Patients with a rare disease affecting their sight have experienced quick vision improvements that sustained for the full yearlong Penn Medicine study, with some experiencing a 10,000-fold improvement in their vision.

Meagan Raeke

‘Ripple Effect’ explores higher education
A college student sitting on a bench outside a university building.

Image: iStock/Santiaga

‘Ripple Effect’ explores higher education

The latest installments of The Wharton School’s faculty research podcast, “Ripple Effect,” delves into the latest issues facing higher education, from paying athletes to AI in the classroom.

From Knowledge at Wharton

Weight management drug does not increase risk of depression or suicidal behavior
A person opening the top of a semaglutide prescription pen.

Image: iStock/imyskin

Weight management drug does not increase risk of depression or suicidal behavior

In new clinical trials, researchers from Penn Medicine find that for people without known major psychopathology, taking semaglutide for weight loss are at no increased risk of mental health issues.

From Penn Medicine News