While people with cancer have options to participate in cancer clinical trials (CCTs), it can be challenging when they encounter difficulties enrolling and remaining in the trial. Trial withdrawal, although every participant’s right, can thwart study goals and hamper advancing novel treatments.
Until now, little attention has focused on what influences retention after participants are enrolled in the trial, especially the role of perceived benefits and burdens. A new investigation from the School of Nursing has examined the association between patients’ perceived benefits and burdens of research participation and CCT retention. It found that patients perceived important benefits from CCT participation, which was associated with trial retention, even among those who also perceived substantial burdens.
“The findings of how perceptions of benefits and burdens were associated with CCT withdrawal outcomes provide novel and foundational evidence of the importance of understanding these perceptions for trial retention,” says Connie M. Ulrich, Lillian S. Brunner Chair in Medical and Surgical Nursing, professor of nursing and professor of medical ethics and health policy at Penn Nursing. Ulrich is the lead investigator of the study.
The study found that when perceived benefits were equal to or greater than perceived burdens, participants were less likely to withdraw than those who perceived the burdens to be greater than the benefits. How participants think about benefits and burdens in a research trial may differ from how researchers and IRBs discern the trial’s acceptability.
Read more at Penn Nursing News.
