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  • Versatile ‘chemoproteomic probes’ for activity-based protein profiling

    A new study uses organohydrazine probes to map chemical reactivty across the proteome, allowing for a diverse classes of proteins and biological pathways to be studied.
    an abstract globe with DNA helixes, a brain outline, and chemical symbols
    New research from the lab of Megan Matthews describes a versatile method for mapping hundreds of diverse enzyme sites and protein functions. These new findings enable diverse classes of proteins and biological pathways to be profiled and specific, targeted therapeutics to be developed for a broad range of diseases. (Image: Matthews Lab)

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  • Exposure to air pollution worsens Alzheimer’s disease
    Emissions from a power plant.

    Image: Pencho Chukov via Getty Images

    Exposure to air pollution worsens Alzheimer’s disease

    New research from Penn Medicine finds living in areas with high concentration of air pollution is associated with increased buildup of amyloid and tau proteins in the brains of Alzheimer’s patients, accelerating cognitive decline.

    Sep 9, 2025

    What stiffening lung tissue reveals about the earliest stages of fibrosis
    Donia Ahmed prepares tissue for imaging.

    Image: Courtesy of Penn Engineering Today

    What stiffening lung tissue reveals about the earliest stages of fibrosis

    A Penn Engineering team has targeted the lung’s extracellular matrix to better understand early fibrosis by triggering the formation of special chemical bonds that increase tissue stiffness in specific locations, mimicking the first physical changes that may lead to lung fibrosis.

    Sep 12, 2025