Stentix wins the 2025 Y-Prize The Stentix team (top) Summer Cobb and Amanda Kossoff, (bottom) Aarsha Shah and Elizabeth Jia, with judges (descending left) Matt Fitz-Henry, Jason Smith, Jennifer Gilburg, and Sasha Schrode, and (descending right) David Hsu, Gerald Lopez, and Dean Miller.(Image: Courtesy of the William and Phyllis Mack Institute for Innovation Management) Stentix wins the 2025 Y-Prize The winning team of Penn Engineering’s annual award for entrepreneurial technology have created a noninvasive mechanism to adjust medical stent positioning using magnetic reconfiguration.
Borrowing nature’s blueprint: How scientists replicated bone marrow The new chip will allow for automated experiments, and can be connected to chip-based models of other organ systems, like the lungs.(Image: Dan Huh) Borrowing nature’s blueprint: How scientists replicated bone marrow A collaborative research team from Penn Engineering, Penn Medicine, and the Children’s Hospital of Philadelphia have developed a chip that mimics human bone marrow.
BEND lipids improve LNP mRNA delivery and gene editing A sample of the new lipids, which improve the success rate of lipid nanoparticles delivering their contents.(Image: Sylvia Zhang) BEND lipids improve LNP mRNA delivery and gene editing Penn Engineering researchers have developed a new class of lipids called branched endosomal disruptor (BEND) lipids to better deliver mRNA and gene-editing tools.
Breakthroughs in gene editing and expression control with mvGPT Sherry Gao, Tyler Daniel (pictured), and their coauthors have developed a new tool that can simultaneously and independently edit multiple genes and regulate their expression.(Image: Bella Ciervo) Breakthroughs in gene editing and expression control with mvGPT Penn Engineers have created a gene editing tool that can address different genetic diseases in the same cell.
Penn Center for Innovation celebrates 10 years (Image: Eric Sucar) Penn Center for Innovation celebrates 10 years The University’s nexus for technology transfer supports researchers in their innovative efforts, from CAR T to mRNA advancements that have dramatically reshaped the world.
Unlocking the brain: Peptide-guided nanoparticles deliver mRNA to neurons Emily Han is a doctoral student in the Mitchell Lab in Penn’s School of Engineering and Applied Science.(Image: Bella Ciervo) Unlocking the brain: Peptide-guided nanoparticles deliver mRNA to neurons Researchers in the lab of Michael Mitchell in Penn Engineering have developed a method for delivering lipid nanoparticles across the blood-brain barrier specifically to targeted neurons.
Brain research could help patients with paralysis move again Iahn Cajigas and researcher Qasim Qureshi review data to identify consistent patterns in brain activity that will enable them to predict a patient’s intention to move in real time.(Image: Courtesy of Penn Medicine News) Brain research could help patients with paralysis move again Penn Medicine researchers are using machine learning to study the areas of the brain that control movement.
How fungi make a key medicinal molecule Image: Bella Ciervo How fungi make a key medicinal molecule New research from Penn Medicine has uncovered the catalyst that creates a compound in fungi whose derivatives are applied to treatments for cancer and inflammation.
A lipid nanoparticle delivers an mRNA cure for preeclampsia Kelsey Swingle at work in the lab of Michael Mitchell.(Image: Kevin Monko) A lipid nanoparticle delivers an mRNA cure for preeclampsia Doctoral student Kelsey Swingle developed a lipid nanoparticle that delivers an mRNA therapeutic that reduces maternal blood pressure through the end of gestation and improves fetal health and blood circulation in the placenta.
In mouse studies, new hope against a dangerous complication of pregnancy Penn In the News HealthDay In mouse studies, new hope against a dangerous complication of pregnancy Doctoral student Kelsey Swingle in the School of Engineering and Applied Science and colleagues are using mRNA molecules to treat pre-eclampsia, a common pregnancy complication.