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Bioengineering

How fungi make a key medicinal molecule
A petri dish of fungal matter in a lab.

Image: Bella Ciervo

How fungi make a key medicinal molecule

New research from Penn Medicine has uncovered the catalyst that creates a compound in fungi whose derivatives are applied to treatments for cancer and inflammation.

Ian Scheffler

A lipid nanoparticle delivers an mRNA cure for preeclampsia
Kelsey Swingle working in a lab.

Kelsey Swingle at work in the lab of Michael Mitchell.

(Image: Kevin Monko)

A lipid nanoparticle delivers an mRNA cure for preeclampsia

Doctoral student Kelsey Swingle developed a lipid nanoparticle that delivers an mRNA therapeutic that reduces maternal blood pressure through the end of gestation and improves fetal health and blood circulation in the placenta.

Melissa Pappas

Refining lipid nanoparticles for better mRNA therapies
Microscopic rendering of mRNA inside a lipid nanoparticle.

Image: iStock/Love Employee

Refining lipid nanoparticles for better mRNA therapies

A new method developed by Penn engineers for designing ionizable lipids is expected to have broad implications for mRNA-based vaccines and therapeutics.

Ian Scheffler

Penn fourth-year Om Gandhi is a 2025 Rhodes Scholar
Om Gandhi.

Penn fourth-year Om Gandhi has been awarded a 2025 Rhodes Scholarship. 

(Image: Courtesy of Om Gandhi)

Penn fourth-year Om Gandhi is a 2025 Rhodes Scholar

Penn fourth-year Om Gandhi, from Barrington, Illinois, has been awarded a 2025 Rhodes Scholarship, which funds tuition and a living stipend for graduate study at the University of Oxford in England. He is among 32 American Rhodes Scholars, and an expected 100 worldwide.
Developing kidneys from scratch
Rendering of kidneys.

Image: iStock/Vladyslav Severyn

Developing kidneys from scratch

Bioengineering professor Alex Hughes tackles the burden of chronic kidney disease by creating kidney tissue from scratch, which could reduce the need for both dialysis and transplantation.

Ian Scheffler

New class of encrypted peptides offer hope in fight against antibiotic resistance
Microscopic view of a string of amino acids.

Image: iStock/Christoph Burgstedt

New class of encrypted peptides offer hope in fight against antibiotic resistance

New research by César de la Fuente finds that nearly 90% of peptides discovered exhibit significant antimicrobial properties, particularly through the disruption of bacterial membranes.

From Penn Medicine News