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Cancer Research

Genetic switch turns tumor suppressor into oncogene in colorectal cancer
Fluorescent microscopy of colon cancer cells..

(Image: Yuhua Tian)

Genetic switch turns tumor suppressor into oncogene in colorectal cancer

Researchers from the School of Veterinary Medicine have shown that an enzyme that suppresses early-stage colorectal cancer switches to become an oncogene as the cancer progresses.

Liana F. Wait

An immunotherapy strategy against all blood cancers
Microscopic rendering of a white blood cell amongst red blood cells.

Image: iStock/PhonlamaiPhoto

An immunotherapy strategy against all blood cancers

Researchers at Penn Medicine have demonstrated a new potential treatment using CAR T cell therapy using a CRISPR base-editing to develop a method called “epitope editing.”

From Penn Medicine News

Carl June on the boundless potential of CAR T cell therapy
Carl June with a microphone in the Penn Medicine atrium with the celebratory flash mob.

Carl June, at the flash mob celebration of the FDA approval of the CAR T cell therapy he developed, in August 2017.

(Image: Courtesy of Penn Medicine Magazine)

Carl June on the boundless potential of CAR T cell therapy

In a Q & A, June, the Richard W. Vague Professor in Immunotherapy, and Daniel Baker, a fourth-year doctoral student in Penn’s Cell and Molecular Biology department, discuss how the treatment can extend to treating diseases beyond cancer.

From Penn Medicine News

QR code for cancer cells
Microscopic view of a DNA chain disintegrating.

Image: iStock/ktsimage

QR code for cancer cells

Researchers from Penn Engineering have created a new synthetic biology approach to uncover why some cells become resistant to anti-cancer therapies.

From Penn Engineering Today

Antibody treatment prevents graft versus host disease in advanced preclinical tests
microscopic view of bone marrow

(Image: Courtesy of Penn Medicine News)

Antibody treatment prevents graft versus host disease in advanced preclinical tests

Penn Medicine, Dana-Farber Cancer Institute, and Boston Children’s Hospital research finds single antibody treatment blocked donor T-cell attack and increased survival rates in preclinical models.

From Penn Medicine News