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mRNA Research
Refining lipid nanoparticles for better mRNA therapies
Refining lipid nanoparticles for better mRNA therapies
A new method developed by Penn engineers for designing ionizable lipids is expected to have broad implications for mRNA-based vaccines and therapeutics.
Novel mRNA vaccine prevents and treat C. difficile
Novel mRNA vaccine prevents and treat C. difficile
Penn Medicine and the Children’s Hospital of Philadelphia have developed the first mRNA vaccine against C. difficile to successfully ward off the bacterial infection.
Siloxane-enhanced nanoparticles chart a new path in precision mRNA medicine
Siloxane-enhanced nanoparticles chart a new path in precision mRNA medicine
By adjusting the chemical structure of lipid nanoparticles Penn Engineers have discovered how to target specific organs, a major breakthrough in precision medicine.
A year after the Nobel Prize, Penn’s mRNA research is revving up
A year after the Nobel Prize, Penn’s mRNA research is revving up
In 2023, Drew Weissman and Katalin Karikó received Nobel Prize recognition for mRNA vaccines. Today, the work continues apace as successes across the University show how medicine is changing rapidly as a result of the prize-winning discovery.
Katalin Karikó, Nobel Laureate and pioneering mRNA researcher, named to Distinguished Daughters of Pennsylvania
Katalin Karikó, Nobel Laureate and pioneering mRNA researcher, named to Distinguished Daughters of Pennsylvania
Karikó was honored by Pennsylvania Governor Josh Shapiro at a special ceremony in Harrisburg.
Understanding the cellular mechanisms driving solid tumors’ robust defense system
Understanding the cellular mechanisms driving solid tumors’ robust defense system
Researchers from Penn have identified a “forcefield-like” defense system in solid tumors and the genetic elements that can switch it off.
Three from Penn elected to the American Philosophical Society
Three from Penn elected to the American Philosophical Society
Dawn Bonnell, Katalin Karikó, and Drew Weissman have been recognized for extraordinary achievements in their fields.
Penn pioneers a ‘one-pot platform’ to promptly produce mRNA delivery particles
Penn pioneers a ‘one-pot platform’ to promptly produce mRNA delivery particles
New lipid platform enables rapid synthesis of molecules that can shuttle therapeutics for a range of diseases with a high degree of organ specificity.
New molecules, inspired by space shuttles, advance lipid nanoparticle delivery for weight control
New molecules, inspired by space shuttles, advance lipid nanoparticle delivery for weight control
Penn Engineering researchers have invented a new way to synthesize the key chemical components of lipid nanoparticles that help protect and deliver medicinal payloads.
Penn Vet launches mRNA Research Initiative
Penn Vet launches mRNA Research Initiative
The University of Pennsylvania School of Veterinary Medicine today announced the mRNA Research Initiative to advance veterinary vaccine science.
In the News
The Hill
mRNA vaccine by UPenn scientists could manage bird flu outbreak
Researchers led by Scott Hensley of the Perelman School of Medicine have collaborated with Drew Weissman to develop an mRNA vaccine to treat the H5N1 avian flu.
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6ABC.com
Penn Medicine creates human bird flu vaccine
Researchers at Penn Medicine have created a human bird flu vaccine using mRNA, the same platform as the COVID-19 vaccine.
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Fast Company
Researchers are working on a new mRNA vaccine—this time for bird flu
Researchers led by Scott Hensley of the Perelman School of Medicine are developing an mRNA vaccine for the H5N1 avian flu with support from Nobel Prize cowinner Drew Weissman.
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Deutsche Welle
A vaccine for pancreatic cancer?
Drew Weissman of the Perelman School of Medicine comments on the efficacy of a potential pancreatic cancer vaccine.
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Scientific American
Pancreatic cancer vaccine shows promise in small initial trial
Drew Weissman of the Perelman School of Medicine is supportive of findings about a pancreatic cancer vaccine, though he says larger studies are needed to determine effectiveness.
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