Researchers breathe new life into lung repair Respiratory diseases like influenza and COVID-19 drive inflammatory responses that can cause long-term damage to the lungs and can be difficult to treat. Now, by using techniques that deliver mRNA via lipid nanoparticles, researchers led by Andrew Vaughan of the School of Veterinary Medicine were able to greatly enhance modes of repair for damaged blood vessels in the lung, leading to improved oxygen saturation. (Image: iStock/Mohammed Haneefa Nizamudeen) Researchers breathe new life into lung repair A collaborative effort from teams across Penn culminates in new techniques to repair lung tissue after damage from flu and COVID-19.
Breaching the blood-brain barrier Michael Mitchell (left) and Emily Han (right) examine a microfluidic device used to make LNPs by mixing lipids and mRNA. nocred Breaching the blood-brain barrier A team of researchers in the School of Engineering and Applied Sciences has devised a method to deliver mRNA into the brain using lipid nanoparticles, potentially advancing treatments for Alzheimer’s disease and seizures.
How Penn Medicine is changing the world with mRNA nocred How Penn Medicine is changing the world with mRNA Vaccines are just the beginning of the potential for messenger RNA, the Nobel Prize-winning technology.
Could a single shot heal heart disease? Image: iStock/Prostock-Studio Could a single shot heal heart disease? Experts at Penn Medicine are researching novel treatments for heart disease, including CRISPR gene editing technology, CAR T technology, and mRNA injections.
A space for lifesaving, collaborative work From left to right: J. Larry Jameson, Liz Magill, Drew Weissman, Katalin Karikó, Gov. Josh Shapiro, Kevin B. Mahoney, Jonathan A. Epstein, and James Hoxie.nocred A space for lifesaving, collaborative work Gov. Josh Shapiro, President Liz Magill, and others from the University community celebrated the new home of the Penn Institute for RNA Innovation.
‘A booster for all of us’ Katalin Karikó and Drew Weissman were named winners of the 2023 Nobel Prize in Physiology or Medicine on Monday, Oct. 2. The Penn Medicine community came together to celebrate the duo.nocred ‘A booster for all of us’ The Penn Medicine community gathered Monday afternoon, toasting to Penn’s new Nobel laureates.
Katalin Karikó and Drew Weissman, Penn’s historic mRNA vaccine research team, win 2023 Nobel Prize in Medicine Katalin Karikó and Drew Weissman are the recipients of the 2023 Nobel Prize in Medicine. nocred Katalin Karikó and Drew Weissman, Penn’s historic mRNA vaccine research team, win 2023 Nobel Prize in Medicine The highest honor was bestowed for foundational discoveries that gave the world a vaccine to fight the COVID-19 pandemic.
A wrong number, a cryptic message, and a big Nobel win nocred A wrong number, a cryptic message, and a big Nobel win Nobel Prize winners Katalin Karikó and Drew Weissman share their thoughts on their newly minted honor at a University press conference.
Can the COVID playbook help end malaria? A Sept. 12 Perry World House event, Can the COVID Playbook Help End Malaria?, looked at the historic fight against this disease, along with new developments in mRNA vaccine technologies and lessons learned from the global COVID-19 pandemic. (Image: Gabby Szczepanek) Can the COVID playbook help end malaria? In a Perry World House conversation, Matthew Laurens, Martina Mchenga, and Drew Weissman discussed how lessons from a global pandemic could help in the fight to eradicate malaria.
SCALAR: A microchip designed to transform the production of mRNA therapeutics and vaccines Led by Michael Mitchell and David Issadore of the School of Engineering and Applied Science, a team of researchers has developed a platform that could rapidly accelerate the development of mRNA-based lipid nanoparticle vaccines and therapeutics at both the small and large scale, SCALAR. (Image: iStock / Anatoly Morozov) SCALAR: A microchip designed to transform the production of mRNA therapeutics and vaccines Researchers have developed a platform that could rapidly accelerate the development of mRNA-based lipid nanoparticle vaccines and therapeutics at both the small and largescale, SCALAR.