Penn pioneers a ‘one-pot platform’ to promptly produce mRNA delivery particles Lipid nanoparticles present one of the most advanced drug delivery platforms to shuttle promising therapeutics such as mRNA but are limited by the time it takes to synthesize cationic lipids, a key component. Now, Michael Mitchell and his team at the School of Engineering and Applied Science have developed a faster way to make cationic lipids that are also more versatile, able to carry different kinds of treatments to target specific organs.(Image: iStock / Dr_Microbe) Penn pioneers a ‘one-pot platform’ to promptly produce mRNA delivery particles New lipid platform enables rapid synthesis of molecules that can shuttle therapeutics for a range of diseases with a high degree of organ specificity.
mRNA vaccine by UPenn scientists could manage bird flu outbreak Penn In the News The Hill mRNA vaccine by UPenn scientists could manage bird flu outbreak Researchers led by Scott Hensley of the Perelman School of Medicine have collaborated with Drew Weissman to develop an mRNA vaccine to treat the H5N1 avian flu. Penn Medicine creates human bird flu vaccine Penn In the News 6ABC.com Penn Medicine creates human bird flu vaccine Researchers at Penn Medicine have created a human bird flu vaccine using mRNA, the same platform as the COVID-19 vaccine. Researchers are working on a new mRNA vaccine—this time for bird flu Penn In the News Fast Company Researchers are working on a new mRNA vaccine—this time for bird flu Researchers led by Scott Hensley of the Perelman School of Medicine are developing an mRNA vaccine for the H5N1 avian flu with support from Nobel Prize cowinner Drew Weissman. New molecules, inspired by space shuttles, advance lipid nanoparticle delivery for weight control Like space shuttles using booster rockets to breach the atmosphere, lipid nanoparticles equipped with the new molecule more successfully deliver medicinal payloads. (Image: Courtesy of Penn Engineering) New molecules, inspired by space shuttles, advance lipid nanoparticle delivery for weight control Penn Engineering researchers have invented a new way to synthesize the key chemical components of lipid nanoparticles that help protect and deliver medicinal payloads. Penn Vet launches mRNA Research Initiative Messenger RNA’s (mRNA) flexibility offers promising therapeutic and preventative solutions for a wide array of veterinary pathogens. Penn Vet is unlocking this potential by harnessing mRNA technology for the development of tailored veterinary vaccines. (Image: Adobe Stock) Penn Vet launches mRNA Research Initiative The University of Pennsylvania School of Veterinary Medicine today announced the mRNA Research Initiative to advance veterinary vaccine science. What makes a breakthrough? ‘Eight steps back’ before making it to the finish line (From left to right) Breakthrough Prize recipients Drew Weissman, Virginia M-Y Lee, Katalin Karikó, and Carl June at a reception on Feb. 13. (Image: Courtesy of Penn Medicine News) What makes a breakthrough? ‘Eight steps back’ before making it to the finish line Four of Penn’s Breakthrough Prize recipients, Carl June, Katalin Karikó, Virginia M-Y Lee, and Drew Weissman, were honored at a reception on Feb. 13. Researchers breathe new life into lung repair Respiratory diseases like influenza and COVID-19 drive inflammatory responses that can cause long-term damage to the lungs and can be difficult to treat. Now, by using techniques that deliver mRNA via lipid nanoparticles, researchers led by Andrew Vaughan of the School of Veterinary Medicine were able to greatly enhance modes of repair for damaged blood vessels in the lung, leading to improved oxygen saturation. (Image: iStock/Mohammed Haneefa Nizamudeen) Researchers breathe new life into lung repair A collaborative effort from teams across Penn culminates in new techniques to repair lung tissue after damage from flu and COVID-19. Breaching the blood-brain barrier Michael Mitchell (left) and Emily Han (right) examine a microfluidic device used to make LNPs by mixing lipids and mRNA. nocred Breaching the blood-brain barrier A team of researchers in the School of Engineering and Applied Sciences has devised a method to deliver mRNA into the brain using lipid nanoparticles, potentially advancing treatments for Alzheimer’s disease and seizures. How Penn Medicine is changing the world with mRNA nocred How Penn Medicine is changing the world with mRNA Vaccines are just the beginning of the potential for messenger RNA, the Nobel Prize-winning technology. Load More
Penn Medicine creates human bird flu vaccine Penn In the News 6ABC.com Penn Medicine creates human bird flu vaccine Researchers at Penn Medicine have created a human bird flu vaccine using mRNA, the same platform as the COVID-19 vaccine. Researchers are working on a new mRNA vaccine—this time for bird flu Penn In the News Fast Company Researchers are working on a new mRNA vaccine—this time for bird flu Researchers led by Scott Hensley of the Perelman School of Medicine are developing an mRNA vaccine for the H5N1 avian flu with support from Nobel Prize cowinner Drew Weissman. New molecules, inspired by space shuttles, advance lipid nanoparticle delivery for weight control Like space shuttles using booster rockets to breach the atmosphere, lipid nanoparticles equipped with the new molecule more successfully deliver medicinal payloads. (Image: Courtesy of Penn Engineering) New molecules, inspired by space shuttles, advance lipid nanoparticle delivery for weight control Penn Engineering researchers have invented a new way to synthesize the key chemical components of lipid nanoparticles that help protect and deliver medicinal payloads. Penn Vet launches mRNA Research Initiative Messenger RNA’s (mRNA) flexibility offers promising therapeutic and preventative solutions for a wide array of veterinary pathogens. Penn Vet is unlocking this potential by harnessing mRNA technology for the development of tailored veterinary vaccines. (Image: Adobe Stock) Penn Vet launches mRNA Research Initiative The University of Pennsylvania School of Veterinary Medicine today announced the mRNA Research Initiative to advance veterinary vaccine science. What makes a breakthrough? ‘Eight steps back’ before making it to the finish line (From left to right) Breakthrough Prize recipients Drew Weissman, Virginia M-Y Lee, Katalin Karikó, and Carl June at a reception on Feb. 13. (Image: Courtesy of Penn Medicine News) What makes a breakthrough? ‘Eight steps back’ before making it to the finish line Four of Penn’s Breakthrough Prize recipients, Carl June, Katalin Karikó, Virginia M-Y Lee, and Drew Weissman, were honored at a reception on Feb. 13. Researchers breathe new life into lung repair Respiratory diseases like influenza and COVID-19 drive inflammatory responses that can cause long-term damage to the lungs and can be difficult to treat. Now, by using techniques that deliver mRNA via lipid nanoparticles, researchers led by Andrew Vaughan of the School of Veterinary Medicine were able to greatly enhance modes of repair for damaged blood vessels in the lung, leading to improved oxygen saturation. (Image: iStock/Mohammed Haneefa Nizamudeen) Researchers breathe new life into lung repair A collaborative effort from teams across Penn culminates in new techniques to repair lung tissue after damage from flu and COVID-19. Breaching the blood-brain barrier Michael Mitchell (left) and Emily Han (right) examine a microfluidic device used to make LNPs by mixing lipids and mRNA. nocred Breaching the blood-brain barrier A team of researchers in the School of Engineering and Applied Sciences has devised a method to deliver mRNA into the brain using lipid nanoparticles, potentially advancing treatments for Alzheimer’s disease and seizures. How Penn Medicine is changing the world with mRNA nocred How Penn Medicine is changing the world with mRNA Vaccines are just the beginning of the potential for messenger RNA, the Nobel Prize-winning technology. Load More
Researchers are working on a new mRNA vaccine—this time for bird flu Penn In the News Fast Company Researchers are working on a new mRNA vaccine—this time for bird flu Researchers led by Scott Hensley of the Perelman School of Medicine are developing an mRNA vaccine for the H5N1 avian flu with support from Nobel Prize cowinner Drew Weissman. New molecules, inspired by space shuttles, advance lipid nanoparticle delivery for weight control Like space shuttles using booster rockets to breach the atmosphere, lipid nanoparticles equipped with the new molecule more successfully deliver medicinal payloads. (Image: Courtesy of Penn Engineering) New molecules, inspired by space shuttles, advance lipid nanoparticle delivery for weight control Penn Engineering researchers have invented a new way to synthesize the key chemical components of lipid nanoparticles that help protect and deliver medicinal payloads. Penn Vet launches mRNA Research Initiative Messenger RNA’s (mRNA) flexibility offers promising therapeutic and preventative solutions for a wide array of veterinary pathogens. Penn Vet is unlocking this potential by harnessing mRNA technology for the development of tailored veterinary vaccines. (Image: Adobe Stock) Penn Vet launches mRNA Research Initiative The University of Pennsylvania School of Veterinary Medicine today announced the mRNA Research Initiative to advance veterinary vaccine science. What makes a breakthrough? ‘Eight steps back’ before making it to the finish line (From left to right) Breakthrough Prize recipients Drew Weissman, Virginia M-Y Lee, Katalin Karikó, and Carl June at a reception on Feb. 13. (Image: Courtesy of Penn Medicine News) What makes a breakthrough? ‘Eight steps back’ before making it to the finish line Four of Penn’s Breakthrough Prize recipients, Carl June, Katalin Karikó, Virginia M-Y Lee, and Drew Weissman, were honored at a reception on Feb. 13. Researchers breathe new life into lung repair Respiratory diseases like influenza and COVID-19 drive inflammatory responses that can cause long-term damage to the lungs and can be difficult to treat. Now, by using techniques that deliver mRNA via lipid nanoparticles, researchers led by Andrew Vaughan of the School of Veterinary Medicine were able to greatly enhance modes of repair for damaged blood vessels in the lung, leading to improved oxygen saturation. (Image: iStock/Mohammed Haneefa Nizamudeen) Researchers breathe new life into lung repair A collaborative effort from teams across Penn culminates in new techniques to repair lung tissue after damage from flu and COVID-19. Breaching the blood-brain barrier Michael Mitchell (left) and Emily Han (right) examine a microfluidic device used to make LNPs by mixing lipids and mRNA. nocred Breaching the blood-brain barrier A team of researchers in the School of Engineering and Applied Sciences has devised a method to deliver mRNA into the brain using lipid nanoparticles, potentially advancing treatments for Alzheimer’s disease and seizures. How Penn Medicine is changing the world with mRNA nocred How Penn Medicine is changing the world with mRNA Vaccines are just the beginning of the potential for messenger RNA, the Nobel Prize-winning technology.
New molecules, inspired by space shuttles, advance lipid nanoparticle delivery for weight control Like space shuttles using booster rockets to breach the atmosphere, lipid nanoparticles equipped with the new molecule more successfully deliver medicinal payloads. (Image: Courtesy of Penn Engineering) New molecules, inspired by space shuttles, advance lipid nanoparticle delivery for weight control Penn Engineering researchers have invented a new way to synthesize the key chemical components of lipid nanoparticles that help protect and deliver medicinal payloads.
Penn Vet launches mRNA Research Initiative Messenger RNA’s (mRNA) flexibility offers promising therapeutic and preventative solutions for a wide array of veterinary pathogens. Penn Vet is unlocking this potential by harnessing mRNA technology for the development of tailored veterinary vaccines. (Image: Adobe Stock) Penn Vet launches mRNA Research Initiative The University of Pennsylvania School of Veterinary Medicine today announced the mRNA Research Initiative to advance veterinary vaccine science.
What makes a breakthrough? ‘Eight steps back’ before making it to the finish line (From left to right) Breakthrough Prize recipients Drew Weissman, Virginia M-Y Lee, Katalin Karikó, and Carl June at a reception on Feb. 13. (Image: Courtesy of Penn Medicine News) What makes a breakthrough? ‘Eight steps back’ before making it to the finish line Four of Penn’s Breakthrough Prize recipients, Carl June, Katalin Karikó, Virginia M-Y Lee, and Drew Weissman, were honored at a reception on Feb. 13.
Researchers breathe new life into lung repair Respiratory diseases like influenza and COVID-19 drive inflammatory responses that can cause long-term damage to the lungs and can be difficult to treat. Now, by using techniques that deliver mRNA via lipid nanoparticles, researchers led by Andrew Vaughan of the School of Veterinary Medicine were able to greatly enhance modes of repair for damaged blood vessels in the lung, leading to improved oxygen saturation. (Image: iStock/Mohammed Haneefa Nizamudeen) Researchers breathe new life into lung repair A collaborative effort from teams across Penn culminates in new techniques to repair lung tissue after damage from flu and COVID-19.
Breaching the blood-brain barrier Michael Mitchell (left) and Emily Han (right) examine a microfluidic device used to make LNPs by mixing lipids and mRNA. nocred Breaching the blood-brain barrier A team of researchers in the School of Engineering and Applied Sciences has devised a method to deliver mRNA into the brain using lipid nanoparticles, potentially advancing treatments for Alzheimer’s disease and seizures.
How Penn Medicine is changing the world with mRNA nocred How Penn Medicine is changing the world with mRNA Vaccines are just the beginning of the potential for messenger RNA, the Nobel Prize-winning technology.