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Most who meet proposed CTE criteria do not show disease signs at autopsy
Gloved hand holding a scan of four brains

Image: pangoasis via Getty Images

Most who meet proposed CTE criteria do not show disease signs at autopsy

New research from Penn Medicine finds proposed traumatic encephalopathy syndrome criteria often don’t match CTE pathology at autopsy, raising concerns about misdiagnosis and potential mental health impacts for at-risk groups.

Kelsey Geesler

2 min. read

Specialized RNA molecules could counter ALS neurodegeneration
Microscopic view of mRNA

Image: Courtesy of Penn Medicine

Specialized RNA molecules could counter ALS neurodegeneration

Researchers at Penn Medicine have discovered short RNA chaperones that bind to the primary target of ALS, restore its function, and protect motor neurons in a preclinical model, pointing toward a new RNA-based therapeutic strategy.

From Penn Medicine News

2 min. read

Reimagining a shelter as a supportive space for childhood

The HAVEN team with Liz Donaghue, assistant shelter director, in Jane Addams’ Bright Spaces room.

nocred

Reimagining a shelter as a supportive space for childhood

HAVEN, a winning project of the 2026 President’s Engagement Prize developed by three fourth-year undergraduates, will launch an after-school program for K-5 children at Jane Addams Place, a homeless shelter in North Philadelphia.

3 min. read

How estrogen in the brain impacts stress and trauma response
The human hippocampus.

Image: libre de droit via Getty Images

How estrogen in the brain impacts stress and trauma response

New research from Penn Medicine reveals how estrogen levels in the brain influence vulnerability to stress-related memory problems, helping explain sex differences in PTSD risk.

Eric Horvath

2 min. read

Learning I had Lynch syndrome ‘saved my life’
Dennis Massimo and his sister Lauren Massimo.

Dennis Massimo and his sister Lauren Massimo in 2026.

(Image: Courtesy of Penn Medicine News)

Learning I had Lynch syndrome ‘saved my life’

Dennis Massimo was only 42 and symptom-free when he was diagnosed with colorectal cancer, thanks to a research study he signed up for with the Penn Medicine BioBank nearly a decade earlier.

2 min. read

Who, What, Why: Katelyn Candido on improving surgical procedures and keeping health care human-first
Katelyn Candido sitting on a staircase, smiling and facing forward, wearing a white coat and blue scrubs in the Perelman School of Medicine

Katelyn Candido, a second-year medical student at PSOM and aspiring neurosurgeon, researches a novel tool’s utility for improving surgical precision.

nocred

  • Who, What, Why

    • Who, What, Why: Katelyn Candido on improving surgical procedures and keeping health care human-first

    Second-year medical student Katelyn Candido shares insight into her research project on a promising tool for improving surgical precision and efficiency, and why she aims to drive equitable patient care through a career in neurosurgery.

    3 min. read

    No brain, no gain: Neuronal activity enhances benefits of exercise
    Rendering of the human body on a bicycle and the brain and skeletal system highlighted.

    Image: Sciepro/Science Photo Library via Getty Images

    No brain, no gain: Neuronal activity enhances benefits of exercise

    Research led by Penn neuroscientist J. Nicholas Betley and collaborators finds that hypothalamic neurons are essential for translating physical exertion into endurance, potentially opening the door to exercise-mimicking therapies.

    5 min. read