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Does heat travel differently in tight spaces?
Green-tinted image showing thermal plumes in a Hele-Shaw cell, illustrating heat transfer in confined spaces.

Hugo Ulloa and Daisuke Noto of the School of Arts & Sciences have unearthed findings that address long-standing mysteries in the mechanics of fluids in confined, tight spaces: how their boundaries affect heat as it emanates from one place and dissipates throughout the space. The image above is a lab-scale hydrothermal system modeled utilizing a Hele-Shaw cell of 10 cm tall, 20 cm long and 4 mm gap. The interior of the Hele-Shaw cell is filled with degassed, deionized water heated from the bottom and cooled from above. A green laser sheet crosses the middle plane of the cell to visualize the motions of micro-scale particles seeded on the water, allowing researchers to estimate the fluid velocity and temperature.

 

 

(Image: Courtesy of Daisuke Noto)

Does heat travel differently in tight spaces?

New research led by Penn scientists offers insights into fundamental problems in fluid mechanics, findings that pave the way for more efficient heat transfer in myriad systems.
Penn pioneers a ‘one-pot platform’ to promptly produce mRNA delivery particles
3D illustration showing cross-section of the lipid nanoparticle carrying mRNA of the virus entering a human cell.

Lipid nanoparticles present one of the most advanced drug delivery platforms to shuttle promising therapeutics such as mRNA but are limited by the time it takes to synthesize cationic lipids, a key component. Now, Michael Mitchell and his team at the School of Engineering and Applied Science have developed a faster way to make cationic lipids that are also more versatile, able to carry different kinds of treatments to target specific organs.

(Image: iStock / Dr_Microbe)

Penn pioneers a ‘one-pot platform’ to promptly produce mRNA delivery particles

New lipid platform enables rapid synthesis of molecules that can shuttle therapeutics for a range of diseases with a high degree of organ specificity.
Social media use is associated with more frequent vaccination
A hand liking the text “I got vaccinated!”

Image: iStock/Anton Vierietin

Social media use is associated with more frequent vaccination

Researchers from the Annenberg Public Policy Center found that more social media use actually correlates with more vaccination, but the reasons differ between Democrats and Republicans.

From the Annenberg Public Policy Center

A first, physical system to learn nonlinear tasks without a traditional computer processor
Contrastive local learning network.

University of Pennsylvania physics and engineering researchers have created a contrastive local learning network, an analog system that is fast, low-power, scalable, and able to learn nonlinear tasks.

(Image: Erica Moser)

A first, physical system to learn nonlinear tasks without a traditional computer processor

Physics and engineering researchers created a contrastive local learning network that is fast, low-power, and scalable.
New insights on cellular clones and inflammation in bones
Hajishengallis, an expert in the immune mechanisms behind the gum disease periodontitis

Hajishengallis, an expert in the immune mechanisms behind the gum disease periodontitis, worked with an international team to show that the innate immune system--typically thought to lack immune memory--can in fact be trained to "remember" past threats.

New insights on cellular clones and inflammation in bones

Research led by George Hajishengallis of Penn Dental sheds light on an aging-related condition that drives inflammation in older populations.
How deadly parasites choose to be male
Transcription atlas of Cryptosporidium life cycle.

Penn Vet researchers developed the Cryptosporidium single-cell atlas, revealing which genes are expressed at which points across the parasite’s life cycle. On the left, the atlas shows parasites replicating asexually in green, with males in blue and females in pink. On the right, micrographs of the stages are shown, with their nuclei highlighted in green.

(Image: Boris Striepen)

How deadly parasites choose to be male

Penn Vet researchers reveal the gene expression across the life cycle of Cryptosporidium and identify the determinant of maleness.