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Breaching the blood-brain barrier
Researchers Mike Mitchell and Emily Han examining a microfluidic device used to make LNPs by mixing lipids and mRNA.

Michael Mitchell (left) and Emily Han (right) examine a microfluidic device used to make LNPs by mixing lipids and mRNA. 

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Breaching the blood-brain barrier

A team of researchers in the School of Engineering and Applied Sciences has devised a method to deliver mRNA into the brain using lipid nanoparticles, potentially advancing treatments for Alzheimer’s disease and seizures.
Two-and-a-half decades of research in Malawi
Malawi Longitudinal Study of Families and Health Collaborators on the Malawi Longitudinal Study of Families and Health visited the University of Pennsylvania in October for a project meeting. Pictured are Lauren Schmitz (University of Wisconsin-Madison), Namrata Ray (Penn), Hans-Peter Kohler (Penn), Kondwani Katundu (Kamuzu University of Health Sciences in Malawi), Kazione Kulisewa (Kamuzu University), Iliana V. Kohler (Penn), and Victor Mwapasa (Kamuzu University).

(Image: Eric Sucar)

Two-and-a-half decades of research in Malawi

As the country’s life expectancy has risen, the Malawi Longitudinal Study of Families and Health has shifted its current and future research to aging.
Climate change and atmospheric dynamics unveil future weather extremes
Canal middle agricultural dry by drought and heatwave on summer. water crisis and water stress on summer during long term drought on summer.

A collaborative team of researchers led by Michael Mann of the School of Arts & Sciences have found the interplay of natural systems and human-induced climate change are setting the stage for more frequent and severe weather events.

(Image/iStock / Piyaset)

Climate change and atmospheric dynamics unveil future weather extremes

A collaborative team of researchers led by Michael Mann of the School of Arts & Sciences have found the interplay of natural systems and human-induced climate change are setting the stage for more frequent and severe weather events.
In hot water: Coral resilience in the face of climate change
scuba diver researching coral

Researchers led by Katie Barott collect data from coral populations in Kanohe Bay, Hawaii. 

(Image: Courtesy of Kristen Brown)

In hot water: Coral resilience in the face of climate change

Over a decade, researchers from Penn studied coral species in Hawaii to better understand their adaptability to the effects of climate change.
More than skin deep: A molecular and mechanistic look at pigmentation variation
Two men sitting and smiling for a photgraph

PIK Professor Sarah Tishkoff led a collaborative team of researchers who have discovered key insights into the molecular basis of skin color differences among Africans. “There’s so much genetic diversity in African populations, but they’ve also been historically underrepresented in studies,” Tishkoff says. “Our findings offer more information on these populations and paint a clearer picture of human evolution.”

(Image: Courtesy of Sarah Tishkoff and Alessia Ranciaro)

More than skin deep: A molecular and mechanistic look at pigmentation variation

A new collaborative study offers a better understanding of genes and variants responsible for skin color, providing insights into human evolution and local adaptation.
Dark Energy Survey uncovers clues to universe’s complexity
an image of a spiral galaxy

An image of NGC 1365 collected by the Dark Energy Survey. Also known as the Great Barred Spiral Galaxy, NGC 1365 is an example of a spiral galaxy and is located about 56 million light-years away. (Image: DECam, DES Collaboration)

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Dark Energy Survey uncovers clues to universe’s complexity

The decade-long effort reveals findings consistent with standard cosmological models, but open to more complex interpretations.