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Novel coupled nanopore platform offers greater precision for detecting molecules
Artist depiction of DNA moving through a nanopore system.

Marija Drndić of the School of Arts & Sciences and Dimitri Monos of the Perelman School of Medicine and Children’s Hospital of Philadelphia led a team of researchers who developed a new nanostructure platform that allows for more precise detection and control of biomolecules, such as DNA and proteins. This exciting new platform signals a new era of synthetic biology, paving the way for enhanced DNA sequencing and protein conformation detection.

(Image: Courtesy of artist) 

Novel coupled nanopore platform offers greater precision for detecting molecules

An interdisciplinary team of researchers from Penn have created the first ever reusable coupled nanopore platform for detecting and guiding molecules, findings could pave the way for much improved DNA sequencing and molecule identification.
A climate expert’s return to Penn
Portrait of Jen Wilcox

Jen Wilcox has returned to the Kleinman Center for Energy Policy at the Stuart Weitzman School of Design and to the School of Engineering and Applied Science following three years in at the U.S. Department of Energy, where she served in the Biden Administration as the principal deputy assistant secretary for the Office of Fossil Energy and Carbon Management.

(Image: Courtesy of Jen Wilcox)

A climate expert’s return to Penn

Jen Wilcox, an expert on direct-air capture, is the inaugural faculty appointment in the Kleinman Center and served for three years as principal deputy assistant secretary for the Office of Fossil Energy in the U.S. Department of Energy. She discusses her time away and her return to Penn.
Sound research as a lens to understanding the world
Illustration of a person wearing headphones with swirling whales and birds surrounding them.

Image: Maggie Chiang for OMNIA

Sound research as a lens to understanding the world

Researchers across Penn’s School of Arts & Sciences are turning to sound for new answers to questions on subjects from birdsong to the benefits of music exposure.

Laura Dattaro

Does heat travel differently in tight spaces?
Green-tinted image showing thermal plumes in a Hele-Shaw cell, illustrating heat transfer in confined spaces.

Hugo Ulloa and Daisuke Noto of the School of Arts & Sciences have unearthed findings that address long-standing mysteries in the mechanics of fluids in confined, tight spaces: how their boundaries affect heat as it emanates from one place and dissipates throughout the space. The image above is a lab-scale hydrothermal system modeled utilizing a Hele-Shaw cell of 10 cm tall, 20 cm long and 4 mm gap. The interior of the Hele-Shaw cell is filled with degassed, deionized water heated from the bottom and cooled from above. A green laser sheet crosses the middle plane of the cell to visualize the motions of micro-scale particles seeded on the water, allowing researchers to estimate the fluid velocity and temperature.

 

 

(Image: Courtesy of Daisuke Noto)

Does heat travel differently in tight spaces?

New research led by Penn scientists offers insights into fundamental problems in fluid mechanics, findings that pave the way for more efficient heat transfer in myriad systems.
Penn pioneers a ‘one-pot platform’ to promptly produce mRNA delivery particles
3D illustration showing cross-section of the lipid nanoparticle carrying mRNA of the virus entering a human cell.

Lipid nanoparticles present one of the most advanced drug delivery platforms to shuttle promising therapeutics such as mRNA but are limited by the time it takes to synthesize cationic lipids, a key component. Now, Michael Mitchell and his team at the School of Engineering and Applied Science have developed a faster way to make cationic lipids that are also more versatile, able to carry different kinds of treatments to target specific organs.

(Image: iStock / Dr_Microbe)

Penn pioneers a ‘one-pot platform’ to promptly produce mRNA delivery particles

New lipid platform enables rapid synthesis of molecules that can shuttle therapeutics for a range of diseases with a high degree of organ specificity.
Researchers upend theory about the formation of the Milky Way Galaxy
Visualization of a ‘wrinkly’ halo of stars around the Milky Way.

This image visualizes the Milky Way and its surrounding “halo” of stars. Most stars in the Milky Way lie in the disc (like the Sun, for example), but stars from past collisions end up in the halo, a large “cloud” of stars that extends outwards in all directions. These halo stars have been enhanced in this image, but in reality would be very dim compared to the disc. The halo appears messy and “wrinkly” here, a sign that a merger has occurred relatively recently.

(Image: Halo stars: ESA/Gaia/DPAC, T Donlon et al. 2024; Background Milky Way and Magellanic Clouds: Stefan Payne-Wardenaar)

Researchers upend theory about the formation of the Milky Way Galaxy

New findings by Robyn Sanderson and collaborators suggest galaxy’s last major collision was billions of years later than previously thought.
Fungi on the front lines against environmental injustice
Mycellium growing in soil.

Image: iStock/Kichigin

Fungi on the front lines against environmental injustice

The collective efforts of the Symbiotic Architecture for Environmental Justice research community are making former industrial sites reborn as vibrant community gardens, and safe, green spaces for children to play a reality.

From the Environmental Innovations Initiative

Teaching climate change communication, from the classroom to a conference of journalists
Michael Mann at a podium and Kathleen Hall Jameson beside him teaching a course at Penn.

The class included writing a letter to the editor, op-ed, and fact-check. “We threw a lot at them, we’re asking a lot of them, but I feel like they’re rising to the occasion,” Mann said.

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Teaching climate change communication, from the classroom to a conference of journalists

Michael Mann and Kathleen Hall Jamieson are co-teaching the Climate Change and Communication course this spring, tied to the Society of Environmental Journalists annual conference, held this year at Penn.
2024 tropical cyclone prediction
View of Hurricane Ida from space with satellite visible above orbit.

An image of Hurricane Ida taken aboard the International Space Station shortly before the Category 4 storm made landfall in Louisiana on Aug. 29, 2021. It marked the ninth named hurricane of the 2021 Atlantic season. As such storms increase in both frequency and intensity, Penn researchers argue that the resilience methods used in the past won’t work in the future.

 (Image: European Space Agency)

2024 tropical cyclone prediction

Michael Mann and colleagues predict a record-breaking 33 named storms for the 2024 North Atlantic hurricane season. It is the highest count ever projected.